辣椒素使豚鼠回肠肌间神经丛释放乙酰胆碱的神经化学证据。
Neurochemical evidence for the release of acetylcholine from the guinea-pig ileum myenteric plexus by capsaicin.
作者信息
Barthó L, Vizi E S
出版信息
Eur J Pharmacol. 1985 Mar 26;110(1):125-7. doi: 10.1016/0014-2999(85)90038-x.
PMID:4007048
Abstract
Superfusion of the sensory stimulant drug capsaicin (3.3 microM) released [3H]acetylcholine from isolated myenteric plexus-longitudinal muscle strips of guinea-pig ileum, preincubated with [3H]choline. This effect was prevented by tetrodotoxin. There was a fast tachyphylaxis to the effect of capsaicin. It is suggested that capsaicin-sensitive nerve endings capable of activating intrinsic cholinergic neurones are situated in the myenteric plexus of the guinea-pig ileum.
摘要
用[³H]胆碱预孵育豚鼠回肠分离的肌间神经丛-纵肌条，再用感觉刺激药物辣椒素（3.3微摩尔）进行灌流，可释放出[³H]乙酰胆碱。这种效应可被河豚毒素阻断。对辣椒素的效应存在快速耐受性。提示豚鼠回肠肌间神经丛中存在能够激活内在胆碱能神经元的对辣椒素敏感的神经末梢。
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