乙酰胆碱对豚鼠回肠电诱发释放[3H] - 乙酰胆碱的调节作用。
Modulation by acetylcholine of the electrically-evoked release of [3H]-acetylcholine from the ileum of the guinea-pig.
作者信息
Fosbraey P, Johnson E S
出版信息
Br J Pharmacol. 1980 May;69(1):145-9. doi: 10.1111/j.1476-5381.1980.tb10894.x.
Abstract
1 Acetylcholine (ACh) stores within neurones of the myenteric plexus of the guinea-pig were labelled with [3H]-choline and the influence of unlabelled ACh, atropine, or atropine and unlabelled ACh on the electrically-evoked output of [3H]-ACh was evaluated. 2 Electrical transmural stimulation (5 Hz) of the ileum led to an increase in the output of [3H]-ACh over that released spontaneously. Superfusion with unlabelled ACh (6.8 microM) caused a marked reduction in the release of [3H]-ACh which was reversed by atropine (3.5 microM). Atropine itself had no effect on the electrically-evoked [3H]-ACh. 3 These experiments provide further evidence for the existence in the guinea-pig ileum of neuronal muscarinic receptors for ACh subserving an inhibitory role on transmitter release.
摘要
- 用[3H] - 胆碱标记豚鼠肌间神经丛神经元内的乙酰胆碱（ACh），并评估未标记的ACh、阿托品或阿托品与未标记的ACh对电诱发的[3H] - ACh释放的影响。2. 对回肠进行电透壁刺激（5Hz）导致[3H] - ACh的释放量比自发释放量增加。用未标记的ACh（6.8μM）进行灌流导致[3H] - ACh的释放显著减少，而阿托品（3.5μM）可逆转这种减少。阿托品本身对电诱发的[3H] - ACh没有影响。3. 这些实验为豚鼠回肠中存在ACh的神经元毒蕈碱受体提供了进一步的证据，该受体对递质释放起抑制作用。
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本文引用的文献
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THE ORIGIN OF THE ACETYLCHOLINE RELEASED SPONTANEOUSLY FROM THE GUINEA-PIG ISOLATED ILEUM.从豚鼠离体回肠中自发释放的乙酰胆碱的来源。
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Release-modulating acetylcholine receptors in cholinergic neurones of the guinea-pig ileum.豚鼠回肠胆碱能神经元中释放调节型乙酰胆碱受体。
Br J Pharmacol. 1980 Feb;68(2):289-300. doi: 10.1111/j.1476-5381.1980.tb10418.x.
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Stimulating action of atropine on the release of acetylcholine by rat cerebral cortex in vitro.阿托品对大鼠大脑皮层体外释放乙酰胆碱的刺激作用。
Br J Pharmacol. 1971 Apr;41(4):600-6. doi: 10.1111/j.1476-5381.1971.tb07068.x.
4
Depression of acetylcholine release from cerebral cortical slices by cholinesterase inhibition and by oxotremorine.通过胆碱酯酶抑制和氧化震颤素抑制大脑皮质切片中乙酰胆碱的释放。
Nat New Biol. 1973 Jan 24;241(108):121-2. doi: 10.1038/newbio241121a0.
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The origin of acetylcholine released from guinea-pig intestine and longitudinal muscle strips.豚鼠肠道和纵肌条释放的乙酰胆碱的来源。
J Physiol. 1968 Jan;194(1):13-33. doi: 10.1113/jphysiol.1968.sp008392.
6
Storage and release of labelled acetylcholine in the myenteric plexus of the guinea-pig ileum.豚鼠回肠肌间神经丛中标记乙酰胆碱的储存与释放
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Inhibition by oxotremorine of acetylcholine resting release from guinea pig-ileum longitudinal muscle strips.毒蕈震颤素对豚鼠回肠纵肌条乙酰胆碱静息释放的抑制作用。
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Muscarinic feedback inhibition of acetylcholine release from the myenteric plexus in the quinea pig ileum and its status after chronic exposure to morphine.豚鼠回肠肌间神经丛乙酰胆碱释放的毒蕈碱反馈抑制及其长期暴露于吗啡后的状态。
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Muscarinic modulation of acetylcholine release evoked by dimethylphenylpiperazinium and high potassium from guinea-pig myenteric plexus.毒蕈碱对由二甲基苯基哌嗪和高钾从豚鼠肠肌丛诱发的乙酰胆碱释放的调节作用。
Eur J Pharmacol. 1978 Aug 15;50(4):385-91. doi: 10.1016/0014-2999(78)90144-9.
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