乙酰胆碱对豚鼠回肠电诱发释放[3H] - 乙酰胆碱的调节作用。
Modulation by acetylcholine of the electrically-evoked release of [3H]-acetylcholine from the ileum of the guinea-pig.
作者信息
Fosbraey P, Johnson E S
出版信息
Br J Pharmacol. 1980 May;69(1):145-9. doi: 10.1111/j.1476-5381.1980.tb10894.x.
Abstract
1 Acetylcholine (ACh) stores within neurones of the myenteric plexus of the guinea-pig were labelled with [3H]-choline and the influence of unlabelled ACh, atropine, or atropine and unlabelled ACh on the electrically-evoked output of [3H]-ACh was evaluated. 2 Electrical transmural stimulation (5 Hz) of the ileum led to an increase in the output of [3H]-ACh over that released spontaneously. Superfusion with unlabelled ACh (6.8 microM) caused a marked reduction in the release of [3H]-ACh which was reversed by atropine (3.5 microM). Atropine itself had no effect on the electrically-evoked [3H]-ACh. 3 These experiments provide further evidence for the existence in the guinea-pig ileum of neuronal muscarinic receptors for ACh subserving an inhibitory role on transmitter release.
摘要
- 用[3H] - 胆碱标记豚鼠肌间神经丛神经元内的乙酰胆碱（ACh），并评估未标记的ACh、阿托品或阿托品与未标记的ACh对电诱发的[3H] - ACh释放的影响。2. 对回肠进行电透壁刺激（5Hz）导致[3H] - ACh的释放量比自发释放量增加。用未标记的ACh（6.8μM）进行灌流导致[3H] - ACh的释放显著减少，而阿托品（3.5μM）可逆转这种减少。阿托品本身对电诱发的[3H] - ACh没有影响。3. 这些实验为豚鼠回肠中存在ACh的神经元毒蕈碱受体提供了进一步的证据，该受体对递质释放起抑制作用。
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