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卵巢小细胞癌合并黏液腺癌的复合癌:1例报告及文献复习

Compound cancer with small cell carcinoma and mucinous adenocarcinoma of the ovary: a case report and literature review.

作者信息

Peng Wan, Hu Hui, Huang Genhua, Wu Xiaoyun, Zhu Yichen, Yang Tian, Tao Xin, Tan Buzhen

机构信息

Department of Obstetrics and Gynecology, The Second Affiliated Hospital, Jiangxi Medical College, Nanchang University, Nanchang, China.

Department of Pathology, The Second Affiliated Hospital, Jiangxi Medical College, Nanchang University, Nanchang, China.

出版信息

Front Oncol. 2025 Feb 25;15:1500088. doi: 10.3389/fonc.2025.1500088. eCollection 2025.

DOI:10.3389/fonc.2025.1500088
PMID:40071085
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC11893415/
Abstract

Primary small cell carcinoma of the ovary is an extremely rare and highly malignant ovarian malignancy. The tissue origin of this type of cancer is still unclear, and it is characterized by rapid progression and a discouraging prognosis. The clinical presentation of small cell carcinoma of the ovary lacks specificity, and there are currently no effective treatment options available. Therefore, it is crucial to improve the understanding and identification of this disease. In this paper, we present a case of composite small cell carcinoma of the ovary with mucinous adenocarcinoma and provide a comprehensive review of the relevant literature.

摘要

原发性卵巢小细胞癌是一种极其罕见且恶性程度很高的卵巢恶性肿瘤。这类癌症的组织起源仍不清楚,其特点是进展迅速且预后不佳。卵巢小细胞癌的临床表现缺乏特异性,目前尚无有效的治疗方案。因此,提高对该疾病的认识和识别至关重要。在本文中,我们报告了一例伴有黏液腺癌的复合性卵巢小细胞癌病例,并对相关文献进行了全面综述。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7526/11893415/d3aecbf60415/fonc-15-1500088-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7526/11893415/b3362f8b475e/fonc-15-1500088-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7526/11893415/8efd6f45d1f2/fonc-15-1500088-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7526/11893415/d73529fc5f95/fonc-15-1500088-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7526/11893415/d3aecbf60415/fonc-15-1500088-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7526/11893415/b3362f8b475e/fonc-15-1500088-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7526/11893415/8efd6f45d1f2/fonc-15-1500088-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7526/11893415/d73529fc5f95/fonc-15-1500088-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7526/11893415/d3aecbf60415/fonc-15-1500088-g004.jpg

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Compound cancer with small cell carcinoma and mucinous adenocarcinoma of the ovary: a case report and literature review.卵巢小细胞癌合并黏液腺癌的复合癌:1例报告及文献复习
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本文引用的文献

1
Small Cell Carcinoma of the Ovary, Hypercalcemic Type (SCCOHT): Patient Characteristics, Treatment, and Outcome-A Systematic Review.卵巢高钙血症型小细胞癌(SCCOHT):患者特征、治疗及预后——一项系统综述
Cancers (Basel). 2023 Jul 26;15(15):3794. doi: 10.3390/cancers15153794.
2
Primary Ovarian Small Cell Carcinoma of Pulmonary Type: Analysis of 6 Cases and Review of 31 Cases in the Literatures.肺型原发性卵巢小细胞癌:6 例分析及文献复习 31 例。
Chin Med Sci J. 2023 Jun 30;38(2):130-137. doi: 10.24920/004183.
3
Prognosis comparison between small cell carcinoma of ovary and high-grade serous ovarian cancer: A retrospective observational cohort study.
卵巢小细胞癌与高级别浆液性卵巢癌的预后比较:一项回顾性观察性队列研究。
Front Endocrinol (Lausanne). 2023 Jan 18;14:1103429. doi: 10.3389/fendo.2023.1103429. eCollection 2023.
4
Small Cell Carcinoma of Ovary, Hypercalcemic Type: A Rare Case Report.卵巢小细胞癌,高钙血症型:一例罕见病例报告
J Pediatr Adolesc Gynecol. 2023 Apr;36(2):112-115. doi: 10.1016/j.jpag.2022.10.004. Epub 2022 Oct 12.
5
Case Report of Small Cell Carcinoma of the Ovary, Hypercalcemic Type (Ovarian Rhabdoid Tumor) with Mutation: A Literature Review of a Rare and Aggressive Condition.卵巢小细胞癌,高钙型(卵巢横纹肌样瘤)伴突变:一种罕见且侵袭性疾病的文献复习。
Curr Oncol. 2022 Jan 18;29(2):411-422. doi: 10.3390/curroncol29020037.
6
Key changes to the World Health Organization (WHO) classification of female genital tumours introduced in the 5th edition (2020).世界卫生组织(世卫组织)女性生殖器官肿瘤分类的重大修订第五版(2020 年)。
Histopathology. 2022 Apr;80(5):762-778. doi: 10.1111/his.14609. Epub 2022 Feb 20.
7
A Rare Presentation of Dual Ovarian Pathologies: Small Cell Carcinoma of the Ovary and Mucinous Ovarian Cancer.双发性卵巢病变的罕见表现:卵巢小细胞癌和黏液性卵巢癌
Cureus. 2021 Nov 11;13(11):e19468. doi: 10.7759/cureus.19468. eCollection 2021 Nov.
8
Global Cancer Statistics 2020: GLOBOCAN Estimates of Incidence and Mortality Worldwide for 36 Cancers in 185 Countries.《全球癌症统计数据 2020:全球 185 个国家和地区 36 种癌症的发病率和死亡率估计》。
CA Cancer J Clin. 2021 May;71(3):209-249. doi: 10.3322/caac.21660. Epub 2021 Feb 4.
9
ESGO-SIOPE guidelines for the management of adolescents and young adults with non-epithelial ovarian cancers.ESGO-SIOPE 指南:青少年和年轻女性非上皮性卵巢癌的管理。
Lancet Oncol. 2020 Jul;21(7):e360-e368. doi: 10.1016/S1470-2045(20)30091-7.
10
Small-Cell Carcinoma of the Ovary, Hypercalcemic Type-Genetics, New Treatment Targets, and Current Management Guidelines.卵巢小细胞癌,嗜血钙型——遗传学、新的治疗靶点和当前的管理指南。
Clin Cancer Res. 2020 Aug 1;26(15):3908-3917. doi: 10.1158/1078-0432.CCR-19-3797. Epub 2020 Mar 10.