Matar Zainab, Zainon Noor Zainura, Al-Hindi Adnan, Yuliarto Brian
Department of Chemical Engineering, Faculty of Chemical and Energy Engineering, Universiti Teknologi Malaysia (UTM), Skudai, Johor, Malaysia.
Advanced Functional Materials Research Group, Faculty of Industrial Technology, Institut Teknologi Bandung, Bandung, Indonesia.
Chem Biodivers. 2025 Mar 12:e202403451. doi: 10.1002/cbdv.202403451.
Ensuring safe access to water and public health requires the availability of sensitive and fast response detection tools. Traditional detection tools present challenges of duration, procedure intricacy, and the need for trained staff. An advanced approach involves utilizing biosensors and nanomaterials, which have the capacity to detect the target analyte with high sensitivity and specificity in a short time. To date, researchers have created new techniques and materials to improve the sensitivity, detection limit, durability, and real-time analytical capabilities of biosensors. This critical review provides a thorough analysis of recent advances in paper-based nano-biosensors used for detecting waterborne pathogens, along with challenges faced in entering the market and potential solutions. The objective is to provide a comprehensive understanding of the capabilities of biosensors in detecting waterborne diseases, by evaluating technologies based on their range of concentrations and limits of detection. The review analyzed multiple biosensors and evaluated the underlying mechanisms that contribute to their effectiveness in detecting waterborne diseases. The discussion also addressed the influence of including nanomaterials on enhancing the performance of biosensors, specifically in relation to specificity, selectivity, and durability. Additionally, the challenges of translating the proof-of-concept biosensor into market products are discussed with potential solutions. The major findings reveal various biosensor technologies with distinct advantages and limitations. The thorough examination of biosensor technologies and the integration of nanomaterials offers valuable insights for academics, professionals, and policymakers involved in water quality monitoring. Additionally, it advocates for additional research to improve the performance of biosensors and address existing challenges.
确保安全的用水途径和公共卫生需要灵敏且快速响应的检测工具。传统检测工具存在检测耗时、程序复杂以及需要专业人员操作等问题。一种先进的方法是利用生物传感器和纳米材料，它们能够在短时间内高灵敏度、高特异性地检测目标分析物。迄今为止，研究人员已开发出新的技术和材料，以提高生物传感器的灵敏度、检测限、耐用性和实时分析能力。这篇综述对用于检测水传播病原体的纸质纳米生物传感器的最新进展进行了全面分析，并探讨了其进入市场所面临的挑战及潜在解决方案。目的是通过评估不同浓度范围和检测限的技术，全面了解生物传感器在检测水传播疾病方面的能力。该综述分析了多种生物传感器，并评估了其在检测水传播疾病中发挥作用的潜在机制。讨论还涉及了纳米材料对提高生物传感器性能的影响，特别是在特异性、选择性和耐用性方面；此外，还讨论了将概念验证生物传感器转化为市场产品所面临的挑战及潜在解决方案。主要研究结果揭示了各种具有不同优缺点的生物传感器技术。对生物传感器技术的全面审视以及纳米材料的整合，为参与水质监测的学者、专业人员和政策制定者提供了有价值的见解。此外，它还倡导开展更多研究以提高生物传感器的性能并应对现有挑战。
