Jiang Chenguang, Wang Jun, Sun Yifan, Tan Shuping, Percell Shaun M, Zhou Zhenhe, Pan Jen Q, Hall Mei-Hua
The Affiliated Mental Health Center of Jiangnan University, Wuxi Central Rehabilitation Hospital, Wuxi, China.
Psychiatry Research Center, Beijing Huilongguan Hospital, Peking University Huilongguan Clinical Medical School, Beijing, China.
Schizophr Res. 2025 Mar;277:159-168. doi: 10.1016/j.schres.2025.03.004. Epub 2025 Mar 11.
P3a event-related potential (ERP) is considered a potential biomarker for schizophrenia (SZ), can be elicited through both passive two-stimulus and active three-stimulus auditory oddball paradigms. While both types of P3a reflect involuntary attention shifts, the nuanced understanding of what P3a represents in different contexts is important and rarely studied. This study aims to examine correlations between P3a ERPs elicited from different paradigms and associations of each P3a with cognitive function, clinical symptoms, and antipsychotic medication.
Our sample included 178 SZ patients and 127 healthy controls (HC). Data on two-stimulus paradigm, three-stimulus oddball paradigm, Chinese version of MATRICS Consensus Cognitive Battery (MCCB), symptom severity, and medication use were collected.
In both paradigms, SZ group's P3a amplitude was significantly reduced compared to HC's (both p < 0.05). P3a evoked by the two-stimulus paradigm and the three-stimulus paradigm were not correlated (r = -0.06, p = 0.661). Three-stimulus paradigm-P3a was significantly correlated with attention/vigilance (r = 0.27, p = 0.017) in SZ, and with working memory (r = 0.39, p = 0.001) and overall MCCB score (r = 0.25, p = 0.042) in HC. Additionally, the two-stimulus paradigm-P3a correlated with olanzapine equivalent antipsychotic dose (r = -0.26, p = 0.022).
Our findings offer new insights into the role of P3a in clinical research. P3a ERPs from different paradigms may represent functionally distinct components. The context in which the P3a is elicited should be taken into account when discussing its functional or neurocognitive significance.
P3a事件相关电位（ERP）被认为是精神分裂症（SZ）的一种潜在生物标志物，可通过被动双刺激和主动三刺激听觉Oddball范式诱发。虽然这两种类型的P3a都反映了非自愿的注意力转移，但深入理解P3a在不同情境中的意义很重要且很少被研究。本研究旨在探讨不同范式诱发的P3a ERPs之间的相关性，以及每种P3a与认知功能、临床症状和抗精神病药物的关联。
我们的样本包括178例SZ患者和127名健康对照（HC）。收集了双刺激范式、三刺激Oddball范式、中文版MATRICS共识认知成套测验（MCCB）、症状严重程度和药物使用的数据。
在两种范式中，SZ组的P3a波幅均显著低于HC组（均p < 0.05）。双刺激范式诱发的P3a与三刺激范式诱发的P3a无相关性（r = -0.06，p = 0.661）。三刺激范式-P3a在SZ组中与注意力/警觉性显著相关（r = 0.27，p = 0.017），在HC组中与工作记忆（r = 0.39，p = 0.001）和MCCB总分（r = 0.25，p = 0.042）显著相关。此外，双刺激范式-P3a与奥氮平等效抗精神病药物剂量相关（r = -0.26，p = 0.022）。
我们的研究结果为P3a在临床研究中的作用提供了新的见解。不同范式的P3a ERPs可能代表功能上不同的成分。在讨论P3a的功能或神经认知意义时，应考虑其诱发的情境。
