Mental Health Center and Psychiatric Laboratory, the State Key Laboratory of Biotherapy, West China Hospital of Sichuan University, Chengdu, Sichuan, China.
West China Brain Research Center, West China Hospital of Sichuan University, Chengdu, Sichuan, China.
Psychol Med. 2023 Feb;53(3):785-794. doi: 10.1017/S0033291721002130. Epub 2021 Sep 3.
Deficits in event-related potential (ERP) including duration mismatch negativity (MMN) and P3a have been demonstrated widely in chronic schizophrenia (SZ) but inconsistent findings were reported in first-episode patients. Psychotropic medications and diagnosis might contribute to different findings on MMN/P3a ERP in first-episode patients. The present study examined MMN and P3a in first episode drug naïve SZ and bipolar disorder (BPD) patients and explored the relationships among ERPs, neurocognition and global functioning.
Twenty SZ, 24 BPD and 49 age and sex-matched healthy controls were enrolled in this study. Data of clinical symptoms [Positive and Negative Symptoms Scale (PANSS), Young Manic Rating Scale (YMRS), Hamilton Depression Rating Scale (HAMD)], neurocognition [Wechsler Adult Intelligence Scale (WAIS), Cattell's Culture Fair Intelligence Test (CCFT), Delay Matching to Sample (DMS), Rapid Visual Information Processing (RVP)], and functioning [Functioning Assessment Short Test (FAST)] were collected. P3a and MMN were elicited using a passive auditory oddball paradigm.
Significant MMN and P3a deficits and impaired neurocognition were found in both SZ and BPD patients. In SZ, MMN was significantly correlated with FAST ( = 0.48) and CCFT ( = -0.31). In BPD, MMN was significantly correlated with DMS ( = -0.54). For P3a, RVP and FAST scores were significant predictors in SZ, whereas RVP, WAIS and FAST were significant predictors in BPD.
The present study found deficits in MMN, P3a, neurocognition in drug naïve SZ and BPD patients. These deficits appeared to link with levels of higher-order cognition and functioning.
事件相关电位（ERP）中的缺陷，包括时长不匹配负波（MMN）和 P3a，在慢性精神分裂症（SZ）中得到了广泛的证明，但在首发患者中报道的结果不一致。精神药物和诊断可能导致首发患者的 MMN/P3aERP 出现不同的结果。本研究检查了首发未经药物治疗的 SZ 和双相障碍（BPD）患者的 MMN 和 P3a，并探讨了 ERPs、神经认知和整体功能之间的关系。
本研究纳入了 20 名 SZ、24 名 BPD 和 49 名年龄和性别匹配的健康对照者。收集了临床症状[阳性和阴性症状量表（PANSS）、Young 躁狂评定量表（YMRS）、汉密尔顿抑郁评定量表（HAMD）]、神经认知[韦氏成人智力量表（WAIS）、卡特尔文化公平智力测验（CCFT）、延迟匹配样本（DMS）、快速视觉信息处理（RVP）]和功能[功能评估简短测试（FAST）]的数据。使用被动听觉Oddball 范式诱发 P3a 和 MMN。
SZ 和 BPD 患者均存在明显的 MMN 和 P3a 缺陷和神经认知障碍。在 SZ 中，MMN 与 FAST（ = 0.48）和 CCFT（ = -0.31）显著相关。在 BPD 中，MMN 与 DMS（ = -0.54）显著相关。对于 P3a，RVP 和 FAST 评分是 SZ 的显著预测因子，而 RVP、WAIS 和 FAST 是 BPD 的显著预测因子。
本研究发现，未经药物治疗的 SZ 和 BPD 患者存在 MMN、P3a 和神经认知缺陷。这些缺陷似乎与高级认知和功能水平有关。
