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针对胰岛素叠加以解决住院糖尿病患者夜间低血糖问题。

Targeting insulin stacking to address overnight hypoglycaemia in hospitalised patients with diabetes.

作者信息

Moolchandani Priyanka, Patel Satya, Larsen Tyler, Moriates Christopher, Weinreb Jane, Everett Estelle

机构信息

Medicine, University of California Los Angeles, Los Angeles, California, USA

Medicine, VA Greater Los Angeles Healthcare System, Los Angeles, California, USA.

出版信息

BMJ Open Qual. 2025 Mar 12;14(1):e003178. doi: 10.1136/bmjoq-2024-003178.

DOI:10.1136/bmjoq-2024-003178
PMID:40074249
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC11907008/
Abstract

Inpatient hypoglycaemia is a significant concern in patients with diabetes due to its association with increased mortality. At the Veterans Affairs Greater Los Angeles Healthcare System, we developed a project to reduce overnight hypoglycaemia in hospitalised patients with diabetes by addressing insulin stacking, defined as insulin dosed within 4 hours of each other. By delaying the timing of bedtime correctional insulin administration in the electronic health record, we achieved a 28% reduction in the proportion of patients experiencing insulin stacking after one year. This led to significant decreases in overnight hypoglycaemia.

摘要

住院患者低血糖是糖尿病患者的一个重大问题,因为它与死亡率增加有关。在洛杉矶退伍军人事务部大洛杉矶医疗保健系统,我们开展了一个项目,通过解决胰岛素叠加问题来减少住院糖尿病患者的夜间低血糖,胰岛素叠加定义为在彼此4小时内给药的胰岛素。通过在电子健康记录中延迟睡前校正胰岛素的给药时间,我们在一年后将经历胰岛素叠加的患者比例降低了28%。这导致夜间低血糖显著减少。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ed17/11907008/a3574011716e/bmjoq-14-1-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ed17/11907008/a3574011716e/bmjoq-14-1-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ed17/11907008/a3574011716e/bmjoq-14-1-g001.jpg

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本文引用的文献

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Diabetes Care. 2024 Jan 1;47(Suppl 1):S295-S306. doi: 10.2337/dc24-S016.
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Recent Trends in Diabetes-Associated Hospitalizations in the United States.美国糖尿病相关住院治疗的近期趋势。
J Clin Med. 2022 Nov 9;11(22):6636. doi: 10.3390/jcm11226636.
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PREVENTION AND MANAGEMENT OF INSULIN-ASSOCIATED HYPOGLYCEMIA IN HOSPITALIZED PATIENTS.住院患者胰岛素相关低血糖症的预防与管理
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Insulin analogues.胰岛素类似物
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