Posłuszny Martyna A, Chłopecka-Słomińska Magdalena, Cherer Sorphon Suor, Cisse Sekhou, Benarbia Mohammed El Amine, Mendel Marta
Division of Pharmacology and Toxicology, Department of Preclinical Sciences, Institute of Veterinary Medicine, Warsaw University of Life Sciences-SGGW, 166, Nowoursynowska St., 02-786 Warsaw, Poland.
Nor-Feed SAS, 3 Rue Amédéo Avogadro, 49070 Beaucouzé, France.
Animals (Basel). 2025 Feb 21;15(5):626. doi: 10.3390/ani15050626.
Modern societies and policymakers increasingly emphasize the advancement of organic farming practices and the preservation of rural culture. Sheep farming faces several challenges, including environmental impacts, antibiotic usage, and public concerns regarding animal welfare. The purpose of this study was to investigate the effects of extract and its principal phenolic acids on the motility of the sheep jejunum and colon, with the goal of assessing their potential as health-promoting feed additives, particularly in animals with dysmotilities.
The trials were performed on isolated jejunum and colon preparations collected from sheep undergoing routine slaughter. The effect of extracts from and three major phenolic acids (rosmarinic, chlorogenic, and lithospermic) was evaluated to identify their ability to modify the spontaneous and pharmacologically-induced contractility of circular and longitudinal smooth muscle.
Regarding spontaneous contractions: extract, rosmarinic acid, and lithospermic acid caused a significant decrease in spontaneous contractility in the jejunum and colon, while chlorogenic acid exhibited myocontractile effects except for colon circular preparations where the effect was myorelaxant as in the other acids. In the case of ACh-induced contractions, all acids and the extract caused mostly a significant decrease in the magnitude of acetylcholine-induced contractions in both longitudinal and circular smooth muscle strips of the colon and jejunum.
The findings suggest a predominantly myorelaxant effect of the extract and its major phenolic acids on the smooth muscle of the sheep jejunum and colon. These results underscore the potential application of the extract as a feed additive to modulate intestinal motility and address challenges in livestock production.
现代社会和政策制定者越来越强调有机农业实践的推进以及乡村文化的保护。养羊业面临着诸多挑战，包括环境影响、抗生素使用以及公众对动物福利的关注。本研究的目的是调查提取物及其主要酚酸对绵羊空肠和结肠运动性的影响，以评估它们作为促进健康的饲料添加剂的潜力，特别是在患有运动障碍的动物中。
试验在从常规屠宰的绵羊身上采集的离体空肠和结肠标本上进行。评估了提取物以及三种主要酚酸（迷迭香酸、绿原酸和紫草酸）的效果，以确定它们改变环形和纵向平滑肌自发和药理诱导收缩性的能力。
关于自发收缩：提取物、迷迭香酸和紫草酸导致空肠和结肠的自发收缩性显著降低，而绿原酸除了在结肠环形标本中表现出肌松弛作用外，在其他方面表现出肌收缩作用，与其他酸的情况相同。在乙酰胆碱诱导的收缩方面，所有酸和提取物大多导致结肠和空肠纵向和环形平滑肌条中乙酰胆碱诱导收缩的幅度显著降低。
研究结果表明提取物及其主要酚酸对绵羊空肠和结肠平滑肌主要具有肌松弛作用。这些结果强调了提取物作为饲料添加剂调节肠道运动性以及应对畜牧生产挑战的潜在应用。
