具有抗菌和杀真菌活性的杂环类抗抑郁药。

Heterocyclic Antidepressants with Antimicrobial and Fungicide Activity.

作者信息

Zolotareva Darya, Zazybin Alexey, Belyankova Yelizaveta, Bayazit Sarah, Dauletbakov Anuar, Seilkhanov Tulegen, Kemelbekov Ulan, Aydemir Murat

机构信息

School of Chemical Engineering, Kazakh-British Technical University, 59 Tole bi Str., Almaty 050000, Kazakhstan.

Laboratory of Engineering Profile NMR Spectroscopy, Sh. Ualikhanov Kokshetau University, 76 Abay Str., Kokshetau 020000, Kazakhstan.

出版信息

Molecules. 2025 Feb 27;30(5):1102. doi: 10.3390/molecules30051102.

DOI:10.3390/molecules30051102

PMID:40076325

原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC11902072/

Abstract

In this review, the presence of antimicrobial and fungicidal activity in heterocyclic antidepressants was investigated. The already proven connection between the intestinal microbiome and mental health prompted the idea of whether these drugs disrupt the normal intestinal microflora. In addition, there is a serious problem of increasing resistance of microorganisms to antibiotics. In this article, we found that almost all of the antidepressants considered (except moclobemide, haloperidol, and doxepin) have antimicrobial activity and can suppress the growth of not only pathogenic microorganisms but also the growth of bacteria that directly affect mental health (such as , , , , and ).

摘要

在本综述中，研究了杂环类抗抑郁药的抗菌和杀真菌活性。肠道微生物群与心理健康之间已被证实的联系引发了这样一个想法，即这些药物是否会破坏正常的肠道微生物群。此外，微生物对抗生素的耐药性不断增加是一个严重问题。在本文中，我们发现几乎所有被考虑的抗抑郁药（除吗氯贝胺、氟哌啶醇和多塞平外）都具有抗菌活性，不仅可以抑制致病微生物的生长，还可以抑制直接影响心理健康的细菌（如、、、和）的生长。