Li Haokun, Shan Wenbo, Zhao Xi, Sun Wei
Department of Molecular Biology, College of Basic Medical Sciences, Jilin University, Changchun 130021, China.
Int J Mol Sci. 2025 Feb 25;26(5):1965. doi: 10.3390/ijms26051965.
Neutrophils play a key role in inflammatory responses and thrombosis, but their complex interactions in disease pathogenesis are not fully understood. This review examines the multifaceted roles of neutrophils, focusing on their activation, cytokine release, and formation of neutrophil extracellular traps (NETs), which contribute to host defense and thrombosis. We discuss the interaction between inflammation and coagulation, the direct effect of neutrophils on thrombus stability, and their involvement in pathological thrombotic diseases. The therapeutic potential of neutrophil drug loading in the treatment of thrombosis, as well as the clinical implications and future research directions, are highlighted. The aim of this review is to gain insight into the critical neutrophil-inflammation-thrombus axis and its potential as a therapeutic target for thrombotic diseases and to suggest possible directions for neutrophil-loaded drug therapy for thrombosis.
中性粒细胞在炎症反应和血栓形成中起关键作用，但其在疾病发病机制中的复杂相互作用尚未完全明确。本综述探讨了中性粒细胞的多方面作用，重点关注其激活、细胞因子释放以及中性粒细胞胞外陷阱（NETs）的形成，这些因素有助于宿主防御和血栓形成。我们讨论了炎症与凝血之间的相互作用、中性粒细胞对血栓稳定性的直接影响及其在病理性血栓形成疾病中的作用。文中强调了中性粒细胞载药在血栓治疗中的潜在应用，以及其临床意义和未来研究方向。本综述旨在深入了解关键的中性粒细胞 - 炎症 - 血栓轴及其作为血栓形成疾病治疗靶点的潜力，并为血栓的中性粒细胞载药治疗提出可能的方向。
