Almeida Josiane Elizabeth, de Oliveira André Correa, de Castro Alves Carlos Eduardo, Filho Selino Monteiro Costa, de Oliveira Elaine Cristina Pacheco, Zuliani Juliana Pavan, Pontes Gemilson Soares
Graduate Program in Basic and Applied Immunology, Federal University of Amazonas (UFAM), Manaus 69080-900, AM, Brazil.
Analytical Multidisciplinary Support Center, Federal University of Amazonas (UFAM), Manaus 69080-900, AM, Brazil.
Int J Mol Sci. 2025 Mar 3;26(5):2250. doi: 10.3390/ijms26052250.
Natural products, especially specific metabolites found in many medicinal plants, exhibit extensive therapeutic potential due to their diverse biological characteristics. Among these compounds, diterpenes stand out for their active principles described in phytochemical studies. Diterpenes exhibit immunomodulatory effects by influencing the production of cytokines and other signaling molecules involved in the immune response. These actions contribute to achieving a more balanced immune profile. The ability to selectively and harmoniously modulate the immune response positions compounds derived from natural products is a promising research field in the development of immunomodulatory therapies. Due to the broad biological activities of diterpenes, the use of molecular docking emerges as a relevant tool for the quantitative screening of a large number of these substances. This review comprehensively examines the pharmacological potential of diterpenes in modulating the immune system. It highlights the existing experimental evidence supporting the efficacy and safety of these compounds as potential treatment for immune dysfunctions. Ultimately, this review aims to contribute to the development of new therapeutic strategies in this field.
天然产物，尤其是许多药用植物中发现的特定代谢产物，由于其多样的生物学特性而具有广泛的治疗潜力。在这些化合物中，二萜因其在植物化学研究中描述的活性成分而脱颖而出。二萜通过影响细胞因子和其他参与免疫反应的信号分子的产生来发挥免疫调节作用。这些作用有助于实现更平衡的免疫状态。天然产物衍生的化合物具有选择性和协调性地调节免疫反应的能力，这使其成为免疫调节疗法开发中一个有前景的研究领域。由于二萜具有广泛的生物活性，分子对接技术成为定量筛选大量此类物质的相关工具。本综述全面考察了二萜在调节免疫系统方面的药理潜力。它强调了现有实验证据支持这些化合物作为免疫功能障碍潜在治疗方法的有效性和安全性。最终，本综述旨在为该领域新治疗策略的开发做出贡献。
