Qian Chunlin, Wang Yueying, Yuan Quan, Guo Yuchen, Wang Yuan
State Key Laboratory of Oral Diseases & National Center for Stomatology & National Clinical Research Center for Oral Diseases, West China Hospital of Stomatology, Sichuan University, Chengdu, 610041, Sichuan, China.
State Key Laboratory of Oral Diseases & National Center for Stomatology & National Clinical Research Center for Oral Diseases, West China Hospital of Stomatology, Sichuan University, Chengdu, 610041, Sichuan, China.
Eur J Pharmacol. 2025 Jun 15;997:177542. doi: 10.1016/j.ejphar.2025.177542. Epub 2025 Mar 25.
The itaconate family, comprising itaconate derivatives, endogenous isomers, and other related compounds, has demonstrated substantial immunoregulatory properties. These compounds exhibit significant therapeutic potential in various disease models by modulating metabolic pathways, signal transduction cascades, and post-translational modifications. In this review, we delineate the structural characteristics and biological functions of the members of the itaconate family and elucidate their immunomodulatory mechanisms. Additionally, we summarize the immunomodulatory effects of the itaconate family across various disease categories, including cardiovascular, liver, respiratory, bone and cartilage, neurological, and autoimmune diseases. This review aims to deepen our understanding of the itaconate family and its potential applications, providing new perspectives and therapeutic strategies for inflammatory disorders and autoimmune diseases.
衣康酸盐家族由衣康酸盐衍生物、内源性异构体和其他相关化合物组成，已显示出显著的免疫调节特性。这些化合物通过调节代谢途径、信号转导级联反应和翻译后修饰，在各种疾病模型中展现出巨大的治疗潜力。在本综述中，我们阐述了衣康酸盐家族成员的结构特征和生物学功能，并阐明了它们的免疫调节机制。此外，我们总结了衣康酸盐家族在各种疾病类别中的免疫调节作用，包括心血管疾病、肝脏疾病、呼吸系统疾病、骨骼和软骨疾病、神经系统疾病以及自身免疫性疾病。本综述旨在加深我们对衣康酸盐家族及其潜在应用的理解，为炎症性疾病和自身免疫性疾病提供新的视角和治疗策略。
