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Intensity-dependent gamma electrical stimulation regulates microglial activation, reduces beta-amyloid load, and facilitates memory in a mouse model of Alzheimer's disease.

作者信息

Liu Qian, Contreras Adam, Afaq Muhammad Shan, Yang Weijian, Hsu Daniel K, Russell Michael, Lyeth Bruce, Zanto Theodore P, Zhao Min

机构信息

Institute for Regenerative Cures, Department of Ophthalmology & Vision Science, Department of Dermatology, University of California Davis, Sacramento, CA, 95817, USA.

Institute of Biomedical and Health Engineering, Shenzhen Institutes of Advanced Technology (SIAT), Chinese Academy of Sciences, Shenzhen, China.

出版信息

Cell Biosci. 2023 Jul 28;13(1):138. doi: 10.1186/s13578-023-01085-5.

DOI:10.1186/s13578-023-01085-5
PMID:37507776
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC10386209/
Abstract

BACKGROUND: Gamma sensory stimulation may reduce AD-specific pathology. Yet, the efficacy of alternating electrical current stimulation in animal models of AD is unknown, and prior research has not addressed intensity-dependent effects. METHODS: The intensity-dependent effect of gamma electrical stimulation (GES) with a sinusoidal alternating current at 40 Hz on Aβ clearance and microglia modulation were assessed in 5xFAD mouse hippocampus and cortex, as well as the behavioral performance of the animals with the Morris Water Maze. RESULTS: One hour of epidural GES delivered over a month significantly (1) reduced Aβ load in the AD brain, (2) increased microglia cell counts, decreased cell body size, increased length of cellular processes of the Iba1 + cells, and (3) improved behavioral performance (learning & memory). All these effects were most pronounced when a higher stimulation current was applied. CONCLUSION: The efficacy of GES on the reduction of AD pathology and the intensity-dependent feature provide guidance for the development of this promising therapeutic approach.

摘要
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/02ff/10386209/19199a056a51/13578_2023_1085_Fig5_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/02ff/10386209/cd564ae435da/13578_2023_1085_Fig1_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/02ff/10386209/f82890a10123/13578_2023_1085_Fig2_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/02ff/10386209/fab2ee77bd0e/13578_2023_1085_Fig3_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/02ff/10386209/e565e3c8fec5/13578_2023_1085_Fig4_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/02ff/10386209/19199a056a51/13578_2023_1085_Fig5_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/02ff/10386209/cd564ae435da/13578_2023_1085_Fig1_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/02ff/10386209/f82890a10123/13578_2023_1085_Fig2_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/02ff/10386209/fab2ee77bd0e/13578_2023_1085_Fig3_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/02ff/10386209/e565e3c8fec5/13578_2023_1085_Fig4_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/02ff/10386209/19199a056a51/13578_2023_1085_Fig5_HTML.jpg

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[1]
Intensity-dependent gamma electrical stimulation regulates microglial activation, reduces beta-amyloid load, and facilitates memory in a mouse model of Alzheimer's disease.

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引用本文的文献

[1]
VR-based gamma sensory stimulation: a pilot feasibility study.

Sci Rep. 2025-8-5

[2]
Microglia surveillance is directed toward neuron activation during sustained intracortical microstimulation.

bioRxiv. 2025-6-12

[3]
Sanshen San Formula Hinders Cognitive Function and Pathology in Alzheimer's Disease Through Potentiating the Function of Synapse.

CNS Neurosci Ther. 2025-4

[4]
Brain Disease-Modifying Effects of Radiofrequency as a Non-Contact Neuronal Stimulation Technology.

Int J Mol Sci. 2025-3-4

[5]
Transcranial alternating current stimulation (tACS) at gamma frequency: an up-and-coming tool to modify the progression of Alzheimer's Disease.

Transl Neurodegener. 2024-6-27

[6]
Transcriptomic analysis of rat brain response to alternating current electrical stimulation: unveiling insights via single-nucleus RNA sequencing.

MedComm (2020). 2024-3-15

[7]
Multimodal Gamma Stimulation Improves Activity but not Memory in Aged Tgf344-AD Rats.

Curr Alzheimer Res. 2024

[8]
Gamma neuromodulation improves episodic memory and its associated network in amnestic mild cognitive impairment: a pilot study.

Neurobiol Aging. 2023-9

本文引用的文献

[1]
Forty-hertz light stimulation does not entrain native gamma oscillations in Alzheimer's disease model mice.

Nat Neurosci. 2023-4

[2]
Impact of multisession 40Hz tACS on hippocampal perfusion in patients with Alzheimer's disease.

Alzheimers Res Ther. 2021-12-20

[3]
Electrically synchronizing and modulating the dynamics of ERK activation to regulate cell fate.

iScience. 2021-10-7

[4]
Decreased Global EEG Synchronization in Amyloid Positive Mild Cognitive Impairment and Alzheimer's Disease Patients-Relationship to .

Brain Sci. 2021-10-16

[5]
Early Deformation of Deep Brain Stimulation Electrodes Following Surgical Implantation: Intracranial, Brain, and Electrode Mechanics.

Front Bioeng Biotechnol. 2021-6-11

[6]
Toward integrative approaches to study the causal role of neural oscillations via transcranial electrical stimulation.

Nat Commun. 2021-4-14

[7]
Exposure to gamma tACS in Alzheimer's disease: A randomized, double-blind, sham-controlled, crossover, pilot study.

Brain Stimul. 2021

[8]
The effect of transcranial alternating current stimulation (tACS) on cognitive function in older adults with dementia.

Annu Int Conf IEEE Eng Med Biol Soc. 2020-7

[9]
Intracranial alternating current stimulation facilitates neurogenesis in a mouse model of Alzheimer's disease.

Alzheimers Res Ther. 2020-7-23

[10]
A Custom Made Electrode Construct and Reliable Implantation Method That Allows for Long-Term Bilateral Deep Brain Stimulation in Mice.

Neuromodulation. 2021-2

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