Cáceres Estévez Irene, Haya Rodriguez Luisa, Haro Perdiguero Elena, Moreno Tovar Francisco Javier, Montalvo Lobo David, Botella Luis Nieto, González Salvador, López Sánchez Ana
Cantabria Labs, 28043 Madrid, Spain.
Department of Medicine and Medical Specialties, Alcalá de Henares University, 28805 Madrid, Spain.
Int J Mol Sci. 2025 Mar 5;26(5):2330. doi: 10.3390/ijms26052330.
There is a need for new technologies in photoprotection. The negative effects of solar exposure on the skin have been amply demonstrated and there is an urgency for the development of alternative photoprotective approaches. In this respect, natural extracts represent the most interesting and promising source. Among them, extracts appear to be an excellent candidate due to supporting evidence, their multiple beneficial biological effects, and their robust toxicological profile. Here, we first explored the photoprotective properties of two different extracts (fermented and unfermented) individually, and then in combination, in a simplified model assessing Normal Human Dermal Fibroblast survival after UVB radiation. Surprisingly, we found the fermented extract to be more photoprotective than the unfermented one. In addition, a specific combination of the two extracts showed a synergistic effect. By HPLC and FRAP analyses, we observed that the photoprotective effect did not correlate with the amount of main characteristic metabolites nor with the antioxidant capacity of the ingredients. Finally, an additional photoprotective effect was observed when extracts were combined with a extract (Fernblock), a well-known botanical ingredient with demonstrated photoprotection activities. Thus, this work provides a solid scientific basis for the inclusion of this technology in future topical and systemic photoprotective strategies.
光保护领域需要新技术。阳光照射对皮肤的负面影响已得到充分证明，因此迫切需要开发替代的光保护方法。在这方面，天然提取物是最具吸引力和前景的来源。其中，由于有支持证据、具有多种有益的生物学效应以及良好的毒理学特性，[提取物名称]提取物似乎是一个极佳的选择。在此，我们首先在一个评估紫外线B辐射后正常人皮肤成纤维细胞存活率的简化模型中，分别探究了两种不同的[提取物名称]提取物（发酵的和未发酵的）的光保护特性，然后研究了它们组合后的光保护特性。令人惊讶的是，我们发现发酵提取物的光保护作用比未发酵提取物更强。此外，两种提取物的特定组合显示出协同效应。通过高效液相色谱（HPLC）和铁还原抗氧化能力（FRAP）分析，我们观察到光保护作用与[提取物名称]主要特征代谢物的含量以及成分的抗氧化能力均无关。最后，当[提取物名称]提取物与一种[提取物名称]提取物（Fernblock，一种具有已证实光保护活性的著名植物成分）组合时，观察到了额外的光保护作用。因此，这项工作为将该技术纳入未来的局部和全身光保护策略提供了坚实的科学依据。
