Miler I, Vĕtvicka V, Síma P, Táborský L
Folia Microbiol (Praha). 1985;30(3):267-71.
Using an in vitro phagocytic assay with synthetic 2-hydroxyethylmethacrylate copolymer particles, the phagocytic activity of leukocytes of bilirubin-treated mice (85 and 170 mumol/L in 0.5 mL intraperitoneally) was studied. Bilirubin treatment significantly stimulated the phagocytosis of both peripheral blood granulocytes and monocytes; the increase of phagocytosis persisted for 6 h after bilirubin injection. The potential immunostimulating and/or immunotoxic effect of bilirubin is discussed.
采用含合成甲基丙烯酸羟乙酯共聚物颗粒的体外吞噬试验，研究了经胆红素处理的小鼠（腹腔注射0.5 mL，浓度分别为85和170 μmol/L）白细胞的吞噬活性。胆红素处理显著刺激了外周血粒细胞和单核细胞的吞噬作用；胆红素注射后6小时内吞噬作用持续增强。文中讨论了胆红素潜在的免疫刺激和/或免疫毒性作用。
