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胆红素和光胆红素对新生儿及成人T淋巴细胞和粒细胞的抑制作用。

Inhibitory effects of bilirubin and photobilirubin on neonatal and adult T lymphocytes and granulocytes.

作者信息

Rubaltelli F F, Granati B, Fortunato A, Piovesan A, Casara G, Colleselli P, Semenzato G

出版信息

Biol Neonate. 1982;42(3-4):152-8. doi: 10.1159/000241589.

DOI:10.1159/000241589
PMID:6982728
Abstract

The lymphoproliferative response to phytohemagglutinin of lymphocytes and spontaneous motility, chemotaxis and phagocytic activity of granulocytes were studied in the newborn and adult blood in the presence of bilirubin and photobilirubin. All of these activities were inhibited to the same extent by these substances. In addition, a significant difference between newborn and adult values was found. In conclusion, the authors suggest that phototherapy does not decrease bilirubin cellular toxicity.

摘要

在胆红素和光胆红素存在的情况下,研究了新生儿和成人血液中淋巴细胞对植物血凝素的淋巴细胞增殖反应以及粒细胞的自发运动、趋化性和吞噬活性。这些物质对所有这些活性的抑制程度相同。此外,还发现新生儿和成人的值存在显著差异。总之,作者认为光疗不会降低胆红素的细胞毒性。

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Inhibitory effects of bilirubin and photobilirubin on neonatal and adult T lymphocytes and granulocytes.胆红素和光胆红素对新生儿及成人T淋巴细胞和粒细胞的抑制作用。
Biol Neonate. 1982;42(3-4):152-8. doi: 10.1159/000241589.
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引用本文的文献

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T-lymphocyte transformation in experimental obstructive jaundice: the role of serum-suppressive factors.实验性梗阻性黄疸中的T淋巴细胞转化:血清抑制因子的作用
World J Surg. 1993 Nov-Dec;17(6):783-5. doi: 10.1007/BF01659096.
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The effect of bilirubin on the Fc receptor expression and phagocytic activity of mouse peritoneal macrophages.胆红素对小鼠腹腔巨噬细胞Fc受体表达及吞噬活性的影响。
Folia Microbiol (Praha). 1985;30(4):373-80. doi: 10.1007/BF02927593.
3
The in vitro cytotoxic effect of bilirubin on human lymphocytes and granulocytes.
胆红素对人淋巴细胞和粒细胞的体外细胞毒性作用。
Folia Microbiol (Praha). 1985;30(3):272-6. doi: 10.1007/BF02923520.
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The effect of bilirubin on the phagocytic activity of mouse peripheral granulocytes and monocytes in vivo.胆红素对小鼠外周粒细胞和单核细胞体内吞噬活性的影响。
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Impaired nonspecific cellular immunity in experimental cholestasis.实验性胆汁淤积中特异性细胞免疫受损。
Ann Surg. 1987 Nov;206(5):578-82. doi: 10.1097/00000658-198711000-00004.
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The stimulatory effect of bilirubin on phagocytic activity.胆红素对吞噬活性的刺激作用。
Folia Microbiol (Praha). 1989;34(2):136-40. doi: 10.1007/BF02823692.
7
The immunosuppressive effects of bilirubin.胆红素的免疫抑制作用。
Folia Microbiol (Praha). 1991;36(2):112-9. doi: 10.1007/BF02814488.
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Management of neonatal hyperbilirubinaemia and prevention of kernicterus.新生儿高胆红素血症的管理与核黄疸的预防。
Drugs. 1992 Jun;43(6):864-72. doi: 10.2165/00003495-199243060-00006.