Pescari Denisa, Mihuta Monica Simina, Bena Andreea, Stoian Dana
Department of Doctoral Studies, "Victor Babeș" University of Medicine and Pharmacy, 300041 Timisoara, Romania.
Center for Molecular Research in Nephrology and Vascular Disease, "Victor Babeș" University of Medicine and Pharmacy, 300041 Timisoara, Romania.
Nutrients. 2025 Feb 26;17(5):798. doi: 10.3390/nu17050798.
Obesity contributes to cardiometabolic risk, including subclinical atherosclerosis and insulin resistance. This study examines the predictive roles of trimethylamine N-oxide (TMAO) and resistin in relation to carotid intima-media thickness and metabolic parameters; : Sixty adults (18-71 years) with varying body weights were assessed for body composition, subclinical atherosclerosis, and blood biomarkers, including TMAO and resistin; : TMAO correlated strongly with CIMT (r = 0.674, < 0.001), indicating its role in subclinical atherosclerosis. Logistic regression identified TMAO (threshold 380; AUC = 0.880, accuracy = 91.7%) as a predictor of cardiometabolic risk. Resistin was associated with CIMT, WHR, and total cholesterol, inversely linked to LDL cholesterol ( = 0.003). Less active participants exhibited higher TMAO ( = 0.001) and resistin ( = 0.02). Family histories of obesity and diabetes correlated with elevated TMAO, while resistin linked to shorter sleep duration and diabetes history, highlighting their importance in obesity-related cardiometabolic risks; : TMAO is strongly linked to abdominal fat, insulin resistance, and subclinical atherosclerosis, while resistin is associated with lipid metabolism and aging. Their combined assessment enhances the prediction of obesity-related cardiometabolic risk, supporting their role in risk stratification and targeted interventions.
肥胖会增加心脏代谢风险，包括亚临床动脉粥样硬化和胰岛素抵抗。本研究探讨了氧化三甲胺（TMAO）和抵抗素与颈动脉内膜中层厚度及代谢参数之间的预测关系；对60名体重各异的成年人（18 - 71岁）进行了身体成分、亚临床动脉粥样硬化及血液生物标志物评估，包括TMAO和抵抗素；TMAO与颈动脉内膜中层厚度（CIMT）密切相关（r = 0.674，P < 0.001），表明其在亚临床动脉粥样硬化中发挥作用。逻辑回归分析确定TMAO（阈值380；AUC = 0.880，准确率 = 91.7%）为心脏代谢风险的预测指标。抵抗素与CIMT、腰臀比（WHR）及总胆固醇相关，与低密度脂蛋白胆固醇呈负相关（P = 0.003）。活动较少的参与者TMAO（P = 0.001）和抵抗素水平较高（P = 0.02）。肥胖和糖尿病家族史与TMAO升高相关，而抵抗素与睡眠时间缩短和糖尿病史有关，凸显了它们在肥胖相关心脏代谢风险中的重要性；TMAO与腹部脂肪、胰岛素抵抗及亚临床动脉粥样硬化密切相关，而抵抗素与脂质代谢和衰老有关。联合评估它们可增强对肥胖相关心脏代谢风险的预测，支持它们在风险分层和靶向干预中的作用。
