Bliss D J, Lote C J
Horm Metab Res. 1985 May;17(5):234-6. doi: 10.1055/s-2007-1013502.
The effect of a range of ovine prolactin doses (10(-9)-10(-6)M) on the short circuit current (Isc), potential difference (E) and electrical resistance (R) of isolated frog skin has been studied. Prolactin produced a dose dependent stimulation of Isc and generally a fall in R, although the latter was only significant after 10(-9) and 10(-6)M prolactin. The effect of prolactin on E was found to be more dependent upon the initial E (at the time of hormone addition) than on the dose of hormone. 10(-9)M prolactin, in contrast to higher doses, produced a sustained fall in R without stimulating Isc. Thus the effect of prolactin on frog skin appears to be predominantly on passive permeability at low doses, and on active ion transport at higher doses.
研究了一系列不同剂量（10⁻⁹ - 10⁻⁶M）的绵羊催乳素对离体青蛙皮肤短路电流（Isc）、电位差（E）和电阻（R）的影响。催乳素对Isc产生剂量依赖性刺激，并且通常使R降低，尽管只有在加入10⁻⁹和10⁻⁶M催乳素后R的降低才具有显著性。发现催乳素对E的影响更多地取决于初始E（添加激素时的E），而不是激素剂量。与较高剂量相比，10⁻⁹M催乳素使R持续降低，而不刺激Isc。因此，催乳素对青蛙皮肤的作用在低剂量时似乎主要影响被动通透性，而在高剂量时影响主动离子转运。
