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在资源匮乏、人口众多的国家,计划性剖宫产术中延迟一期缝合对降低手术部位感染的有效性:一项随机对照试验

Usefulness of delayed primary closure in unplanned caesarean section to reduce surgical site infection in a resource-poor high population country: a randomised controlled trial.

作者信息

Biswas Jhuma, Dasgupta Shyamal, Datta Mallika, Sanyal Poushali, Bhattacharya Namrata, Kamal Mostafa

机构信息

Department of Obstetrics and Gynaecology, Calcutta National Medical College and Hospital, West Bengal, India.

Department of Obstetrics and Gynaecology, R. G. Kar Medical College and Hospital, West Bengal, India.

出版信息

J Turk Ger Gynecol Assoc. 2025 Mar 12;26(1):1-6. doi: 10.4274/jtgga.galenos.2024.2024-7-1.

DOI:10.4274/jtgga.galenos.2024.2024-7-1
PMID:40077938
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC11905179/
Abstract

OBJECTIVE

Surgical site infection (SSI) is a common complication, especially following emergency caesarean section (CS) leading to maternal morbidity and prolonged hospital stay. Results are conflicting regarding the ideal method of skin closure after abdominal surgery in clean contaminated and contaminated wound. To compare the outcome of wound health between primary and delayed primary closure (DPC) of skin incision in emergency CS.

MATERIAL AND METHODS

A total of 70 pregnant women undergoing emergency caesarean deliveries with a history of membrane rupture were randomized into group A (n=40) and group B (n=30). In group A monofilament sutures were placed in skin incision but the wound was left open for daily dressing with normal saline. It was closed by tying the monofilament sutures on fifth day and stitches were removed on seventh day. In group B skin was apposed by a routine primary closure procedure.

RESULTS

No patient in group A required secondary wound closure following SSI (p<0.001) and duration of hospital stay was also significantly reduced (p<0.05).

CONCLUSION

This trial demonstrated that DPC is effective in reduction of requirement of secondary stitches due to SSI in emergency CS.

摘要

目的

手术部位感染(SSI)是一种常见并发症,尤其是在急诊剖宫产(CS)后,会导致产妇发病和住院时间延长。对于清洁-污染和污染伤口的腹部手术后皮肤闭合的理想方法,结果存在争议。比较急诊剖宫产中皮肤切口一期缝合与延迟一期缝合(DPC)后的伤口愈合情况。

材料与方法

共有70例有胎膜破裂史的急诊剖宫产孕妇被随机分为A组(n = 40)和B组(n = 30)。A组在皮肤切口处放置单丝缝线,但伤口敞开,每天用生理盐水换药。在第五天通过系紧单丝缝线闭合伤口,并在第七天拆线。B组采用常规一期缝合方法对皮肤进行对合。

结果

A组没有患者因手术部位感染需要二次伤口缝合(p < 0.001),住院时间也显著缩短(p < 0.05)。

结论

该试验表明,延迟一期缝合在减少急诊剖宫产因手术部位感染而进行二次缝合的需求方面是有效的。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3e11/11905179/16f5b84e1798/JTurkGerGynecolAssoc-26-1-1-figure-1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3e11/11905179/16f5b84e1798/JTurkGerGynecolAssoc-26-1-1-figure-1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3e11/11905179/16f5b84e1798/JTurkGerGynecolAssoc-26-1-1-figure-1.jpg

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本文引用的文献

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Practical Review on Delayed Primary Closure: Basic Science and Clinical Applications.延迟一期缝合的实践综述:基础科学与临床应用
Plast Reconstr Surg Glob Open. 2023 Aug 4;11(8):e5172. doi: 10.1097/GOX.0000000000005172. eCollection 2023 Aug.
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Trends and projections of caesarean section rates: global and regional estimates.剖宫产率的趋势和预测:全球和区域估计。
BMJ Glob Health. 2021 Jun;6(6). doi: 10.1136/bmjgh-2021-005671.
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Delayed primary closure (DPC) of the skin and subcutaneous tissues following complex, contaminated abdominal wall reconstruction (AWR): a propensity-matched study.
复杂污染性腹壁重建(AWR)术后皮肤和皮下组织的延期一期缝合(DPC):一项倾向评分匹配研究。
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Suture compared with staple skin closure after cesarean delivery: a randomized controlled trial.剖宫产术后缝合与皮钉缝合的比较:一项随机对照试验。
Obstet Gynecol. 2014 Jun;123(6):1169-1175. doi: 10.1097/AOG.0000000000000227.
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Risk factors for surgical site infection following caesarean section in England: results from a multicentre cohort study.英国剖宫产术后手术部位感染的危险因素:一项多中心队列研究的结果。
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Postcesarean infection.剖宫产术后感染
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