Chang Tzu-Hsuan, Ho Ping-Chih
Department of Fundamental Oncology, University of Lausanne, 1015 Lausanne, Switzerland.
Ludwig Institute for Cancer Research, University of Lausanne, 1015 Lausanne, Switzerland.
Immune Netw. 2025 Feb 12;25(1):e8. doi: 10.4110/in.2025.25.e8. eCollection 2025 Feb.
IFNs play a critical role in cancer biology, including impacting tumor cell behavior and instructing the tumor microenvironment (TME). IFNs recently have been shown to reprogram tumor metabolism through distinct mechanisms. Furthermore, IFNs shape the TME by modulating immune cell infiltration and function, contributing to the intricate interaction between the tumor and stromal cells. This review summarizes the effects of IFNs on metabolic reprogramming and their impacts on the function of immune cells within the TME, with a particular focus on the dual roles of IFNs in mediating both anti-tumor and pro-tumor immune responses. Understanding the significance of IFNs-mediated processes aids to advise future therapeutic strategies in cancer treatment.
干扰素在癌症生物学中发挥着关键作用，包括影响肿瘤细胞行为和塑造肿瘤微环境（TME）。最近研究表明，干扰素可通过不同机制重塑肿瘤代谢。此外，干扰素通过调节免疫细胞浸润和功能来塑造肿瘤微环境，促进肿瘤细胞与基质细胞之间复杂的相互作用。本综述总结了干扰素对代谢重编程的影响及其对肿瘤微环境中免疫细胞功能的作用，特别关注干扰素在介导抗肿瘤和促肿瘤免疫反应中的双重作用。了解干扰素介导过程的意义有助于为未来癌症治疗的策略提供建议。
