Hidayah Risa Miliawati Nurul, Gunawan Hendra, Fauziah Nisa, Rianty Fathia
Department of Dermatology and Venereology, Faculty of Medicine, Universitas Padjadjaran - Dr. Hasan Sadikin Hospital, Bandung, West Java, Indonesia.
Division of Parasitology, Department of Basic Biomedical Science, Faculty of Medicine, Universitas Padjadjaran, Bandung, West Java, Indonesia.
Int Med Case Rep J. 2025 Mar 8;18:315-320. doi: 10.2147/IMCRJ.S507453. eCollection 2025.
Chromoblastomycosis is a chronic fungal infection of the skin and subcutaneous tissues, caused by melanized fungi. In cases with extensive cutaneous lesions, heat therapy can be used as an adjuvant to systemic antifungal therapy. This case report aimed to demonstrate the efficacy of heat therapy using an electric heating pad as an adjuvant to itraconazole in the treatment of extensive chromoblastomycosis. A 60-year-old immunocompetent male presented with ten-year history of extensive verrucous erythematous plaques with atrophic central lesions located in the right arm. Histology and mycological examination from a direct smear and skin biopsy revealed muriform cells and pathognomonic chromoblastomycosis. Cultures grew dark-pigmented colonies, yielding . A combination therapy of itraconazole 400 mg daily and topical heat therapy using an electric heating pad resulted in clinical improvement during the first month of treatment. Heat therapy can be administered as an adjuvant to systemic antifungal therapy because of its fungistatic and fungicidal effects, and its ability to enhance the patient's immune response. The selection of a suitable heat therapy device is crucial for improving the success of therapy. In this case, the patient demonstrated significant improvement in cutaneous lesions after one month of combination therapy with itraconazole and heat therapy. Electric heating pads are a good choice for topical heat therapy because of their stable temperature, availability, affordability, and ease of use. Heat therapy using electric heating pads is an effective adjuvant to systemic antifungal therapy in the treatment of extensive chromoblastomycosis.
着色芽生菌病是一种由暗色真菌引起的皮肤和皮下组织的慢性真菌感染。对于有广泛皮肤损害的病例,热疗可作为全身抗真菌治疗的辅助手段。本病例报告旨在证明使用电加热垫进行热疗作为伊曲康唑的辅助治疗在广泛着色芽生菌病治疗中的疗效。一名60岁免疫功能正常的男性,有十年右臂广泛疣状红斑斑块伴中央萎缩性损害的病史。直接涂片和皮肤活检组织学及真菌学检查显示有砖形细胞和典型的着色芽生菌病表现。培养长出深色菌落,产生……。每天400毫克伊曲康唑与使用电加热垫的局部热疗联合治疗在治疗的第一个月导致临床改善。热疗可作为全身抗真菌治疗的辅助手段来使用,因为它具有抑菌和杀菌作用,以及增强患者免疫反应的能力。选择合适的热疗设备对于提高治疗成功率至关重要。在本病例中,患者在伊曲康唑和热疗联合治疗一个月后皮肤损害有显著改善。电加热垫因其温度稳定、可获得性、可承受性及使用方便,是局部热疗的一个好选择。使用电加热垫进行热疗是广泛着色芽生菌病全身抗真菌治疗的一种有效辅助手段。