Yuan Zhuochen, Czerpak Cameron A, Kashaf Michael Saheb, Quigley Harry A, Nguyen Thao D
Wilmer Ophthalmological Institute, Johns Hopkins University School of Medicine, Wilmer 120, 400 North Broadway, Baltimore, MD 21287.
Department of Mechanical Engineering, The Johns Hopkins University, Baltimore, MD 21218.
J Biomech Eng. 2025 May 1;147(5). doi: 10.1115/1.4068155.
This study measured the strain response to intraocular pressure (IOP) change in the sclera, choroid, and retina of glaucoma patients whose optic nerve head region was imaged by optical coherence tomography (OCT) before and after IOP-lowering by laser suturelysis following trabeculectomy surgery. The strain response was calculated from digital volume correlation of the prior and after images. The strain response of the sclera, choroid, and retina were compared to those previously published for the anterior lamina cribrosa (ALC). Mean strains were lowest in the retina and highest in the prelaminar neural tissue (PLNT). Maximum principal and maximum shear strains were significantly increased with greater IOP decrease in all five eye regions. Maximum principal and maximum shear strains in the anterior lamina cribrosa and the sclera were significantly related (p = 0.0094). Strain in the radial direction was negative in the ALC and PLNT, but positive in the sclera (p = 0.017). In conclusion, the strain response of the sclera, choroid, and retina is related to the magnitude of IOP change and is smaller than those of the ALC. The strain response of the ALC and sclera are significantly related to each other.
本研究测量了青光眼患者在小梁切除术后通过激光缝线松解降低眼压前后，其巩膜、脉络膜和视网膜对眼压（IOP）变化的应变反应，这些患者的视神经乳头区域在术前和术后通过光学相干断层扫描（OCT）成像。应变反应通过前后图像的数字体积相关性计算得出。将巩膜、脉络膜和视网膜的应变反应与先前发表的关于前筛板（ALC）的应变反应进行比较。平均应变在视网膜中最低，在前层神经组织（PLNT）中最高。在所有五个眼区，随着眼压降低幅度增大，最大主应变和最大剪应变显著增加。前筛板和巩膜中的最大主应变和最大剪应变显著相关（p = 0.0094）。在ALC和PLNT中，径向应变呈负，而在巩膜中呈正（p = 0.017）。总之，巩膜、脉络膜和视网膜的应变反应与眼压变化幅度相关，且小于ALC的应变反应。ALC和巩膜的应变反应彼此显著相关。
