大肠杆菌K-12 ilvA缺失菌株中异亮氨酸-缬氨酸转氨酶的多价调控
Multivalent regulation of isoleucine-valine transaminase in an Escherichia coli K-12 ilvA deletion strain.
作者信息
Kline E L, Manross D N, Warwick M L
出版信息
J Bacteriol. 1977 May;130(2):951-3. doi: 10.1128/jb.130.2.951-953.1977.
Abstract
In a strain of Escherichia coli K-12 lacking threonine deaminase, the enzyme converting alpha-ketoisovalerate and alpha-keto-beta-methylvalerate to valine and isoleucine, respectively, was multivalently repressed by valine, isoleucine, and leucine. This activity was due to transaminase B, specified by the ilvE structural gene.
摘要
在一株缺乏苏氨酸脱氨酶的大肠杆菌K-12中，分别将α-酮异戊酸和α-酮-β-甲基戊酸转化为缬氨酸和异亮氨酸的酶受到缬氨酸、异亮氨酸和亮氨酸的多价阻遏。这种活性归因于转氨酶B，它由ilvE结构基因所编码。
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本文引用的文献
1
Protein measurement with the Folin phenol reagent.使用福林酚试剂进行蛋白质测定。
J Biol Chem. 1951 Nov;193(1):265-75.
2
REGULATORY MECHANISMS IN THE BIOSYNTHESIS OF ISOLEUCINE AND VALINE. II. IDENTIFICATION OF TWO OPERATOR GENES.异亮氨酸和缬氨酸生物合成中的调控机制。II. 两个操纵基因的鉴定
J Bacteriol. 1965 Mar;89(3):654-60. doi: 10.1128/jb.89.3.654-660.1965.
3
Isoleucine and valine metabolism in Escherichia coli. V. alpha-Ketoisovaleric acid accumulation.大肠杆菌中异亮氨酸和缬氨酸的代谢。V. α-酮异戊酸的积累。
J Biol Chem. 1953 Nov;205(1):475-82.
4
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5
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Biochem Biophys Res Commun. 1974 Apr 23;57(4):1144-51. doi: 10.1016/0006-291x(74)90816-x.
6
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Anal Biochem. 1973 Jan;51(1):67-79. doi: 10.1016/0003-2697(73)90453-3.
7
Isoleucine and valine metabolism of Escherichia coli. XV. Biochemical properties of mutants resistant to thiaisoleucine.大肠杆菌的异亮氨酸和缬氨酸代谢。十五。对噻异亮氨酸抗性突变体的生化特性。
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8
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Biochem Biophys Res Commun. 1975 Apr 21;63(4):1048-55. doi: 10.1016/0006-291x(75)90675-0.
9
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J Mol Biol. 1976 Apr 15;102(3):453-65. doi: 10.1016/0022-2836(76)90327-2.
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