大肠杆菌的异亮氨酸和缬氨酸代谢。第十六部分。K - 12菌株中的多价阻遏模式。
Isoleucine and valine metabolism of Escherichia coli. XVI. Pattern of multivalent repression in strain K-12.
作者信息
Dwyer S B, Umbarger H E
出版信息
J Bacteriol. 1968 May;95(5):1680-4. doi: 10.1128/jb.95.5.1680-1684.1968.
Abstract
The levels of the five enzymes required for isoleucine and valine synthesis were examined under several growth conditions in strain K-12 of Escherichia coli and mutants derived from it. In strains with wild type repressibility, the same pattern of derepression was found on limiting isoleucine as is found to be constitutive in strain Tir-8, which has an altered isoleucine-activating enzyme. Homoserine dehydrogenase, which is essential for the biosynthesis of threonine and is normally derepressed on limiting isoleucine or threonine, is also derepressed in strain Tir-8. Threonine deaminase and homoserine dehydrogenase were partially repressed in strain Tir-8 by very high levels of isoleucine, but were not further derepressed over levels in minimal medium by limiting isoleucine.
摘要
在几种生长条件下，对大肠杆菌K-12菌株及其衍生突变体中异亮氨酸和缬氨酸合成所需的五种酶的水平进行了检测。在具有野生型阻遏性的菌株中，在限制异亮氨酸时发现了与Tir-8菌株中组成型表达相同的去阻遏模式，Tir-8菌株的异亮氨酸激活酶发生了改变。高丝氨酸脱氢酶是苏氨酸生物合成所必需的，通常在限制异亮氨酸或苏氨酸时去阻遏，在Tir-8菌株中也被去阻遏。苏氨酸脱氨酶和高丝氨酸脱氢酶在Tir-8菌株中被非常高浓度的异亮氨酸部分阻遏，但在基本培养基中，限制异亮氨酸不会使其进一步去阻遏。
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本文引用的文献
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Isoleucine and valine metabolism in Escherichia coli. XI. Valine inhibition of the growth of Escherichia coli strain K-12.大肠杆菌中异亮氨酸和缬氨酸的代谢。XI. 缬氨酸对大肠杆菌K-12菌株生长的抑制作用。
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REGULATORY MECHANISMS IN THE BIOSYNTHESIS OF ISOLEUCINE AND VALINE. II. IDENTIFICATION OF TWO OPERATOR GENES.异亮氨酸和缬氨酸生物合成中的调控机制。II. 两个操纵基因的鉴定
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Multivalent repression in the biosynthesis of threonine in Salmonella typhimurium and Escherichia coli.鼠伤寒沙门氏菌和大肠杆菌中苏氨酸生物合成的多价阻遏
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Isoleucine and valine metabolism of Escherichia coli. XIV. Effect of thiaisoleucine.大肠杆菌的异亮氨酸和缬氨酸代谢。十四。硫代异亮氨酸的作用。
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J Bacteriol. 1968 May;95(5):1672-9. doi: 10.1128/jb.95.5.1672-1679.1968.
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