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Isotypic and idiotypic characterization of anti-bee venom phospholipase A2 antibodies.

作者信息

Wetterwald A, Skvaril F, Müller U, Blaser K

出版信息

Int Arch Allergy Appl Immunol. 1985;77(1-2):195-7. doi: 10.1159/000233784.

DOI:10.1159/000233784
PMID:4008074
Abstract

It was shown that anti-bee venom phospholipase A2 antibodies (anti-PLA) of bee keepers belong mainly to the IgG4 class. Furthermore anti-PLA of different individuals are idiotypically related to each other. This was shown by the binding of heterologous antiidiotypic antibodies, produced against anti-PLA IgG from single donors, to anti-PLA F(ab')2 of different individuals. Therefore, the anti-PLA response provides a human model to study the idiotypic regulation of isotypes in a defined system.

摘要

相似文献

1
Isotypic and idiotypic characterization of anti-bee venom phospholipase A2 antibodies.
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2
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