Swanson J, Kinsbourne M, Roberts W, Zucker K
Pediatrics. 1978 Jan;61(1):21-9.
This report introduces a method for obtaining behavioral time-response information for a short-acting psychotropic drug (methylphenidate [Ritalin]) that is widely used to treat behaviorally hyperactive children. We used a laboratory learning task to document that between one and two hours after the administration of a single dose of methylphenidate, the drug exerts its maximum effect on performance in a learning task in the laboratory. This effect on cognitive performance dissipates within the same day. This rapid and transient effect of methylphenidate makes it possible to classify patients in a single day into those who respond favorably and those who respond adversely to the drug in terms of its effect on cognitive behavior.
本报告介绍了一种获取短效精神药物（哌甲酯[利他林]）行为时间反应信息的方法，该药物广泛用于治疗行为多动的儿童。我们采用一项实验室学习任务来证明，在单次服用哌甲酯后的一到两小时内，该药物对实验室学习任务中的表现发挥最大作用。这种对认知表现的影响在同一天内消散。哌甲酯这种快速且短暂的作用使得在一天内就能将患者根据药物对认知行为的影响分为对药物反应良好和反应不佳两类。
