Baldwin Ronald L, Chelonis John J, Flake Rebecca A, Edwards Mark C, Feild Charles R, Meaux Julie B, Paule Merle G
Department of Pediatrics, University of Arkansas for Medical Sciences--Arkansas Children's Hospital, Little Rock, AR 72202, USA.
Exp Clin Psychopharmacol. 2004 Feb;12(1):57-64. doi: 10.1037/1064-1297.12.1.57.
The effects of methylphenidate (MPH) on performance of a time-production task were studied in 17 children with attention-deficit/hyperactivity disorder who participated in 1 test session on and 1 off MPH. Participants held a response lever down for at least 10 but no longer than 14 s. Administration of MPH had no effect on the number of correct responses or on the mean duration of lever holds. MPH administration significantly decreased timing response variability, increased holds of 10- to 11-s duration, and decreased lever holds of extremely short durations. These results indicate that administration of MPH resulted in more precise timing performance without changing the mean duration of lever holds, suggesting an enhancement in working memory.
在17名患有注意力缺陷/多动障碍的儿童中，研究了哌甲酯（MPH）对时间生产任务表现的影响。这些儿童参加了一次服用MPH时和一次未服用MPH时的测试。参与者将反应杆按下至少10秒但不超过14秒。服用MPH对正确反应的数量或杆保持的平均持续时间没有影响。服用MPH显著降低了计时反应变异性，增加了持续10至11秒的保持次数，并减少了极短持续时间的杆保持次数。这些结果表明，服用MPH导致计时表现更精确，而不改变杆保持的平均持续时间，这表明工作记忆得到了增强。
