Davis A L, Hulme K L, Wilson G T, McCord T J
Antimicrob Agents Chemother. 1978 Mar;13(3):542-4. doi: 10.1128/AAC.13.3.542.
Against Enterobacter aerogenes 13048, Serratia marcescens 13880, Klebsiella pneumoniae 10031, Pseudomonas aeruginosa 10145, Escherichia coli 9723, Lactobacillus casei 7469, Lactobacillus plantarum 8014, Leuconostoc dextranicum 8086, and Streptococcus faecalis 8043, the mean minimal inhibitory concentrations of three cyclic hydroxamic acids, 3-amino-3,4-dihydro-1-hydroxycarbostyril, the 6-chloro analog, and the 7-chloro analog, were 0.6, 0.6, and 0.2 micrograms/ml, and those of the corresponding lactams, 3-amino-3,4-dihydrocarbostyril, the 6-chloro analog, and the 7-chloro analog, were 60, 60, and 6 micrograms/ml, respectively. Under the same assay conditions the mean minimal inhibitory concentrations of chloramphenicol and kanamycin were both 2 micrograms/ml. In addition, the cyclic hydroxamic acids but not the lactams inhibited the growth of Candida albicans at minimal inhibitory concentrations ranging from 20 to 200 micrograms/ml, at pH 7, as compared with that of amphotericin B, at 2 micrograms/ml.
针对产气肠杆菌13048、粘质沙雷氏菌13880、肺炎克雷伯菌10031、铜绿假单胞菌10145、大肠杆菌9723、干酪乳杆菌7469、植物乳杆菌8014、右旋糖酐明串珠菌8086和粪肠球菌8043，三种环异羟肟酸（3-氨基-3,4-二氢-1-羟基咔唑、6-氯类似物和7-氯类似物）的平均最低抑菌浓度分别为0.6、0.6和0.2微克/毫升，相应内酰胺（3-氨基-3,4-二氢咔唑、6-氯类似物和7-氯类似物）的平均最低抑菌浓度分别为60、60和6微克/毫升。在相同的检测条件下，氯霉素和卡那霉素的平均最低抑菌浓度均为2微克/毫升。此外，在pH值为7时，与两性霉素B（2微克/毫升）相比，环异羟肟酸而非内酰胺在20至200微克/毫升的最低抑菌浓度下抑制白色念珠菌的生长。
