Chin N X, Neu H C
Antimicrob Agents Chemother. 1983 Nov;24(5):754-63. doi: 10.1128/AAC.24.5.754.
Enoxacin is a new quinolone carboxylic acid compound. Its activity against 740 bacterial isolates was determined. It inhibited 90% Escherichia coli, Klebsiella sp., Aeromonas sp., Enterobacter spp., Serratia spp., Proteus mirabilis, and Morganella morganii at less than or equal to 0.8 micrograms/ml. The majority of Pseudomonas aeruginosa was inhibited by less than or equal to 3.1 micrograms/ml. Haemophilus spp. and Neisseria spp. were inhibited by less than 0.1 micrograms/ml. Although most Staphylococcus aureus were inhibited by 3.1 micrograms/ml, some streptococcal species had minimal inhibitory concentrations of 6.3 to 12.5 micrograms/ml and Bacteroides sp. had minimal inhibitory concentrations greater than or equal to 25 micrograms/ml. Activity of enoxacin and norfloxacin was similar. Enoxacin inhibited organisms resistant to cefotaxime, moxalactam, gentamicin, and piperacillin. Enoxacin was less active in urine at an acid pH than in broth, but serum did not decrease minimal inhibitory concentrations or minimal bactericidal concentrations. There was no major difference between minimal inhibitory concentrations and minimal bactericidal concentrations. Resistance frequency development was less than 10(-9) for most bacterial species.
依诺沙星是一种新型喹诺酮羧酸化合物。测定了其对740株细菌分离株的活性。它在小于或等于0.8微克/毫升时可抑制90%的大肠杆菌、克雷伯菌属、气单胞菌属、肠杆菌属、沙雷菌属、奇异变形杆菌和摩根摩根菌。大多数铜绿假单胞菌在小于或等于3.1微克/毫升时被抑制。嗜血杆菌属和奈瑟菌属在小于0.1微克/毫升时被抑制。虽然大多数金黄色葡萄球菌在3.1微克/毫升时被抑制，但一些链球菌的最低抑菌浓度为6.3至12.5微克/毫升，拟杆菌属的最低抑菌浓度大于或等于25微克/毫升。依诺沙星和诺氟沙星的活性相似。依诺沙星可抑制对头孢噻肟、莫西沙星、庆大霉素和哌拉西林耐药的菌株。依诺沙星在酸性pH的尿液中的活性低于在肉汤中的活性，但血清不会降低最低抑菌浓度或最低杀菌浓度。最低抑菌浓度和最低杀菌浓度之间没有显著差异。大多数细菌种类的耐药频率发展低于10^(-9)。
