Zhao Fengnian, Chen Yufei, Dong Ao, Song Keguan
Aviation General Hospital, Beijing, China.
First Affiliated Hospital of Harbin Medical University, Harbin, China.
J Orthop Surg Res. 2025 Mar 14;20(1):282. doi: 10.1186/s13018-025-05661-y.
Radial Extracorporeal Shock Wave Therapy (rESWT) is applied as a conservative treatment modality in orthopedics, yet its effectiveness in addressing aseptic loosening of cementless joint prostheses remains unclear. Through animal experimentation, we have revealed that in a titanium particle-induced osteolysis rat model, rESWT intervention significantly increased periprosthetic bone density compared to untreated controls, concurrently reducing osteolytic lesion area and lowering serum IL-1β levels. Histological analyses demonstrated a relative decrease in osteoclast counts within the treatment group versus non-treated controls. These findings indicate that rESWT, through mechanisms involving anti-inflammatory actions and suppression of osteoclastogenesis, may serve as a non-invasive therapeutic strategy for preventing and managing periprosthetic bone loss, demonstrating clinical potential to delay or eliminate the necessity for revision surgeries.
桡侧体外冲击波疗法（rESWT）在骨科领域作为一种保守治疗方式应用，但它在解决非骨水泥型关节假体无菌性松动方面的有效性仍不明确。通过动物实验，我们发现，在钛颗粒诱导的大鼠骨溶解模型中，与未治疗的对照组相比，rESWT干预显著增加了假体周围骨密度，同时减少了骨溶解病变面积并降低了血清IL-1β水平。组织学分析表明，与未治疗的对照组相比，治疗组破骨细胞数量相对减少。这些发现表明，rESWT通过抗炎作用和抑制破骨细胞生成的机制，可能作为一种预防和管理假体周围骨质流失的非侵入性治疗策略，显示出延迟或消除翻修手术必要性的临床潜力。
