阿拉霍普星，一种由白色链霉菌赭黄亚种新亚种产生的新型二肽抗生素。

Alahopcin, a new dipeptide antibiotic produced by Streptomyces albulus subsp. ochragerus subsp. nov.

作者信息

Higashide E, Horii S, Ono H, Mizokami N, Yamazaki T, Shibata M, Yoneda M

出版信息

J Antibiot (Tokyo). 1985 Mar;38(3):285-95. doi: 10.7164/antibiotics.38.285.

DOI:10.7164/antibiotics.38.285

Abstract

An actinomycete strain No. B-52653 was found to produce an antibiotic selectively active against the in vitro antibiotic resistant mutant of Staphylococcus aureus. Based on taxonomic studies, the name Streptomyces albulus subsp. ochragerus subsp. nov. is proposed for the strain. The microorganism produced two kinds of antibiotics; one identical with gougerotin, the other an amphoteric water soluble dipeptide containing L-alanine. The latter has the molecular formula C9H15N3O6 and is named alahopcin. It has a broad antibacterial spectrum and a synergistic effect with some other antibiotics against some antibiotic resistant staphylococci. Alahopcin has a low toxicity and was effective against experimental infections in mice caused by Staphylococcus aureus.

摘要

发现一株编号为B - 52653的放线菌能产生一种抗生素，该抗生素对金黄色葡萄球菌的体外抗生素抗性突变体具有选择性活性。基于分类学研究，提议将该菌株命名为白色链霉菌赭黄亚种（新亚种）。该微生物产生两种抗生素；一种与谷氏菌素相同，另一种是含有L - 丙氨酸的两性水溶性二肽。后者的分子式为C9H15N3O6，被命名为阿拉霍普星。它具有广泛的抗菌谱，并且与其他一些抗生素对某些耐抗生素葡萄球菌具有协同作用。阿拉霍普星毒性低，对小鼠由金黄色葡萄球菌引起的实验性感染有效。