Yu Ying, Li Minghui
Shaoxing Joint Training Base, Zhejiang Chinese Medical University, Hangzhou, Zhejiang Province, 310053, China.
Department of Infection, Shaoxing People's Hospital, Zhongxing North Road No. 568, Shaoxing, Zhejiang Province, 312000, China.
Mol Biol Rep. 2025 Mar 14;52(1):309. doi: 10.1007/s11033-025-10382-w.
Serious respiratory infections can occur in both in-hospital and out-of-hospital settings. These infections are known as community-acquired pneumonias (CAPs). Streptococcus pneumoniae and other microorganisms commonly cause atypical pneumonia. This study examined the clinical features, medication therapy, and prognosis of 85 cases of community-acquired pneumonia (CAP) caused by Mycoplasma pneumoniae (MPP) and Chlamydia psittaci(C. psittaci)neumoniae (CPP).
A retrospective analysis was conducted at Shaoxing People's Hospital from July 2021 to August 2024, using targeted next-generation sequencing (tNGS) of bronchoalveolar lavage fluid (BALF). Patients were classified into the MPP group (54 patients) and the CPP group (31 patients). Compared with the control group, the CPP group had a significantly lower proportion of patients with a contact history of poultry and birds, a shorter length of hospital stay, and a lower percentage of severe pneumonia cases.
The MPP group demonstrated higher incidences of cough and sputum production; conversely, the occurrences of fever, fatigue, diminished appetite, and generalised myalgia were comparatively lower. The MPP group exhibited markedly diminished levels of neutrophils, C-reactive protein, procalcitonin, erythrocyte sedimentation rate, heparin-binding protein, alanine aminotransferase, aspartate aminotransferase, lactate dehydrogenase, direct bilirubin, pH, lactic acid, and D-dimer compared with the CPP group. In contrast, the MPP group had a markedly higher lymphocyte count, platelet count, albumin levels, as well as higher concentrations of blood sodium and blood chloride. The drug treatment regimens differed between the two groups, resulting in one unfavourable outcome within the MPP group.
In summary, fatigue, fever, and reduced appetite are more prominent symptoms in patients with CPP, whereas cough and sputum production are the primary manifestations of MPP. Pleural effusion is more prevalent in patients with CPP, Additionally, these patients also have increased inflammatory responses and decreased immune function.
严重呼吸道感染可发生在医院内和医院外环境中。这些感染被称为社区获得性肺炎（CAP）。肺炎链球菌和其他微生物通常会引起非典型肺炎。本研究调查了85例由肺炎支原体（MPP）和鹦鹉热衣原体（C. psittaci）肺炎（CPP）引起的社区获得性肺炎（CAP）的临床特征、药物治疗及预后。
于2021年7月至2024年8月在绍兴市人民医院进行回顾性分析，采用支气管肺泡灌洗液（BALF）的靶向二代测序（tNGS）。将患者分为MPP组（54例）和CPP组（31例）。与对照组相比，CPP组有家禽和鸟类接触史的患者比例显著更低，住院时间更短，重症肺炎病例百分比更低。
MPP组咳嗽和咳痰的发生率更高；相反，发热、乏力、食欲减退和全身肌肉疼痛的发生率相对较低。与CPP组相比，MPP组中性粒细胞、C反应蛋白、降钙素原、红细胞沉降率、肝素结合蛋白、丙氨酸转氨酶、天冬氨酸转氨酶、乳酸脱氢酶、直接胆红素、pH值、乳酸和D-二聚体水平明显降低。相比之下，MPP组淋巴细胞计数、血小板计数、白蛋白水平以及血钠和血氯浓度明显更高。两组的药物治疗方案不同，MPP组出现一例不良结局。
总之，乏力、发热和食欲减退在CPP患者中是更突出的症状，而咳嗽和咳痰是MPP的主要表现。CPP患者胸腔积液更常见。此外，这些患者炎症反应增强，免疫功能降低。
