Boon M E, Löwhagen T, Cardozo P L, Blonk D I, Kurver P J, Baak J P
Anal Quant Cytol. 1982 Mar;4(1):1-5.
Morphometric analysis of 23 follicular tumors (13 adenomas and 10 carcinomas) and 10 metastatic lesions from follicular thyroid carcinomas resulted in the identification of five significant parameters between the carcinoma and adenoma groups. With a classification rule using these features, the probability of a histologic diagnosis of adenoma versus carcinoma was computed for each case. Using threshold values of probabilities of 0.25 and 0.75, only 1 of the 33 cases was not correctly classified on the cytologic smear alone; the remaining 32 cases were correctly classified. These results indicate that morphometric analysis in follicular tumors of the thyroid may be of great help in individual patient care if used as a selective method by a well-trained cytopathologist.
对23个滤泡性肿瘤（13个腺瘤和10个癌）以及10个甲状腺滤泡癌转移灶进行形态计量分析，结果确定了癌组和腺瘤组之间的五个重要参数。利用基于这些特征的分类规则，计算了每例病例腺瘤与癌组织学诊断的概率。采用0.25和0.75的概率阈值，33例病例中仅1例仅根据细胞涂片未正确分类；其余32例分类正确。这些结果表明，如果由训练有素的细胞病理学家将形态计量分析用作一种选择性方法，那么它对甲状腺滤泡性肿瘤患者的个体化治疗可能会有很大帮助。
