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点扫描视网膜光学相干断层扫描系统中的瞳孔摆动

Pupil wobble in point-scanning retinal optical coherence tomography systems.

作者信息

Narawane Amit, Ortiz Pablo, Draelos Mark, McNabb Ryan P, Kuo Anthony N, Izatt Joseph A

出版信息

Opt Lett. 2025 Mar 15;50(6):1969-1972. doi: 10.1364/OL.547035.

DOI:10.1364/OL.547035
PMID:40085605
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC12124918/
Abstract

Optical coherence tomography (OCT) systems utilize 2D scanning methods to acquire reflectance-based volumetric images of samples, such as the human retina, with micrometer-scale depth resolution. A common method for performing this scanning at high speeds is to use a pair of sequential, single-axis galvanometer scanners. An undesired effect of using separated scanners is the variation in the beam position at the pupil plane, a phenomenon known as beam wander or pupil wobble. This can lead to loss of signal and vignetting artifacts in the resulting images. To overcome these limitations, we propose a method to deterministically analyze the pupil wobble in a given retinal OCT system and to correct for the displacement using pupil tracking OCT with a 2D scanning mirror placed anti-conjugate to the pupil plane. We demonstrate that we can model the pattern of pupil wobble present in any OCT system both theoretically and empirically and then use a pupil tracking system to correct for the displacement of the beam to acquire OCT images without the imposed artifacts.

摘要

光学相干断层扫描(OCT)系统利用二维扫描方法,以微米级的深度分辨率获取基于反射率的样本体积图像,如人类视网膜。在高速执行这种扫描的一种常用方法是使用一对顺序排列的单轴振镜扫描仪。使用分离扫描仪的一个不良影响是光束在光瞳平面处位置的变化,这种现象称为光束漂移或光瞳摆动。这可能导致所得图像中的信号丢失和渐晕伪影。为了克服这些限制,我们提出了一种方法,用于确定性地分析给定视网膜OCT系统中的光瞳摆动,并使用与光瞳平面反共轭放置的二维扫描镜的瞳孔跟踪OCT来校正位移。我们证明,我们可以在理论上和经验上对任何OCT系统中存在的光瞳摆动模式进行建模,然后使用瞳孔跟踪系统校正光束的位移,以获取没有伪影的OCT图像。

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本文引用的文献

1
Volumetric directional optical coherence tomography.体积定向光学相干断层扫描
Biomed Opt Express. 2022 Jan 21;13(2):950-961. doi: 10.1364/BOE.447882. eCollection 2022 Feb 1.
2
Contactless optical coherence tomography of the eyes of freestanding individuals with a robotic scanner.非接触式光学相干断层扫描对独立个体的眼睛进行检测,使用的是机器人扫描仪。
Nat Biomed Eng. 2021 Jul;5(7):726-736. doi: 10.1038/s41551-021-00753-6. Epub 2021 Jul 12.
3
Controlling for Artifacts in Widefield Optical Coherence Tomography Angiography Measurements of Non-Perfusion Area.控制广角光学相干断层扫描血管造影术中非灌注区测量的伪影。
Sci Rep. 2019 Jun 24;9(1):9096. doi: 10.1038/s41598-019-43958-1.
4
Pupil tracking optical coherence tomography for precise control of pupil entry position.用于精确控制瞳孔入射位置的瞳孔跟踪光学相干断层扫描技术。
Biomed Opt Express. 2015 Aug 17;6(9):3405-19. doi: 10.1364/BOE.6.003405. eCollection 2015 Sep 1.
5
Reflective afocal broadband adaptive optics scanning ophthalmoscope.反射式无焦宽带自适应光学扫描检眼镜。
Biomed Opt Express. 2011 Jun 1;2(6):1757-68. doi: 10.1364/BOE.2.001757. Epub 2011 May 27.
6
Revealing Henle's fiber layer using spectral domain optical coherence tomography.应用谱域光学相干断层扫描技术揭示 Henle 纤维层。
Invest Ophthalmol Vis Sci. 2011 Mar 18;52(3):1486-92. doi: 10.1167/iovs.10-5946. Print 2011 Mar.
7
Adaptive-optics optical coherence tomography for high-resolution and high-speed 3D retinal in vivo imaging.用于高分辨率和高速三维视网膜活体成像的自适应光学光学相干断层扫描技术
Opt Express. 2005 Oct 17;13(21):8532-8546. doi: 10.1364/opex.13.008532.
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Optical coherence tomography of the human retina.人类视网膜的光学相干断层扫描。
Arch Ophthalmol. 1995 Mar;113(3):325-32. doi: 10.1001/archopht.1995.01100030081025.
9
Optical coherence tomography.光学相干断层扫描
Science. 1991 Nov 22;254(5035):1178-81. doi: 10.1126/science.1957169.