用于高分辨率和高速三维视网膜活体成像的自适应光学光学相干断层扫描技术
Adaptive-optics optical coherence tomography for high-resolution and high-speed 3D retinal in vivo imaging.
作者信息
Zawadzki Robert J, Jones Steven M, Olivier Scot S, Zhao Mingtao, Bower Bradley A, Izatt Joseph A, Choi Stacey, Laut Sophie, Werner John S
机构信息
Department of Ophthalmology and Vision Science, UC Davis, 4860 Y Street, Suite 2400, Sacramento, California 95817
出版信息
Opt Express. 2005 Oct 17;13(21):8532-8546. doi: 10.1364/opex.13.008532.
Abstract
We have combined Fourier-domain optical coherence tomography (FD-OCT) with a closed-loop adaptive optics (AO) system using a Hartmann-Shack wavefront sensor and a bimorph deformable mirror. The adaptive optics system measures and corrects the wavefront aberration of the human eye for improved lateral resolution (4 μm) of retinal images, while maintaining the high axial resolution (6 μm) of stand alone OCT. The AO-OCT instrument enables the three-dimensional (3D) visualization of different retinal structures in vivo with high 3D resolution (4×4×6 μm). Using this system, we have demonstrated the ability to image microscopic blood vessels and the cone photoreceptor mosaic.
摘要
我们将傅里叶域光学相干断层扫描（FD-OCT）与使用哈特曼-夏克波前传感器和双压电晶片可变形镜的闭环自适应光学（AO）系统相结合。自适应光学系统测量并校正人眼的波前像差，以提高视网膜图像的横向分辨率（约4μm），同时保持单独OCT的高轴向分辨率（约6μm）。AO-OCT仪器能够以高3D分辨率（4×4×6μm）在体内对不同视网膜结构进行三维（3D）可视化。使用该系统，我们已经证明了对微观血管和视锥光感受器镶嵌进行成像的能力。
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