Gold R L, Bren G B, Katz R J, Varghese P J, Ross A M
J Am Coll Cardiol. 1985 Jul;6(1):119-23. doi: 10.1016/s0735-1097(85)80262-x.
To assess the effects of digoxin as single therapy and in combination with quinidine in the treatment of atrial fibrillation, the atrial fibrillation threshold was determined from the right atrial appendage and Bachmann's bundle in 11 open chest dogs. In group 1 (six dogs), the atrial fibrillation threshold was determined at baseline, post-quinidine (10 mg/kg intravenously) and then post-digoxin (50 micrograms/kg intravenously). In group 2 (five dogs), the order of drug administration was reversed. The results of this study were: 1) Digoxin had no significant effect on the atrial fibrillation threshold when given alone. 2) Quinidine significantly increased the atrial fibrillation threshold (p less than 0.002) and the addition of digoxin resulted in a further increase in threshold (p less than 0.002). 3) Quinidine produced greater suppression of atrial fibrillation induction at the right atrial site than at the Bachmann's bundle site, suggesting differential effects of quinidine on atrial fibers.
为评估地高辛单一疗法以及与奎尼丁联合使用在治疗心房颤动中的效果，在11只开胸犬身上从右心耳和巴赫曼束测定心房颤动阈值。在第1组（6只犬）中，在基线、静脉注射奎尼丁（10毫克/千克）后以及静脉注射地高辛（50微克/千克）后测定心房颤动阈值。在第2组（5只犬）中，药物给药顺序相反。本研究结果如下：1）单独给予地高辛时，对心房颤动阈值无显著影响。2）奎尼丁显著提高了心房颤动阈值（p<0.002），加入地高辛后阈值进一步升高（p<0.002）。3）奎尼丁在右心房部位比在巴赫曼束部位对心房颤动诱发的抑制作用更强，提示奎尼丁对心房纤维有不同作用。
