Hu Qiongjie, Shi Yueli, Wang Huang, Bing Liuwen, Xu Zhiyong
Department of Respiratory and Critical Care Medicine, The Fourth Affiliated Hospital of Zhejiang University School of Medicine, Yiwu, 322000, Zhejiang Province, China.
The Third Affiliated Hospital of Zhejiang, Chinese Meical University, Hangzhou, 310013, China.
Exp Hematol Oncol. 2025 Mar 14;14(1):37. doi: 10.1186/s40164-025-00627-6.
Immunotherapy targeting immune checkpoints has gained traction across various cancer types in clinical settings due to its notable advantages. Despite this, the overall response rates among patients remain modest, alongside issues of drug resistance and adverse effects. Hence, there is a pressing need to enhance immune checkpoint blockade (ICB) therapies. Post-translational modifications (PTMs) are crucial for protein functionality. Recent research emphasizes their pivotal role in immune checkpoint regulation, directly impacting the expression and function of these key proteins. This review delves into the influence of significant PTMs-ubiquitination, phosphorylation, and glycosylation-on immune checkpoint signaling. By targeting these modifications, novel immunotherapeutic strategies have emerged, paving the way for advancements in optimizing immune checkpoint blockade therapies in the future.
由于其显著优势，针对免疫检查点的免疫疗法在临床环境中已在各种癌症类型中获得认可。尽管如此，患者的总体缓解率仍然不高，同时还存在耐药性和副作用问题。因此，迫切需要加强免疫检查点阻断（ICB）疗法。翻译后修饰（PTM）对蛋白质功能至关重要。最近的研究强调了它们在免疫检查点调节中的关键作用，直接影响这些关键蛋白质的表达和功能。本综述深入探讨了重要的PTM（泛素化、磷酸化和糖基化）对免疫检查点信号传导的影响。通过针对这些修饰，已经出现了新的免疫治疗策略，为未来优化免疫检查点阻断疗法的进展铺平了道路。
