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Exposure of monocyte-derived macrophages to the UV-inactivated SARS-CoV-2 VOCs shows similar effects on the transcriptomic profile as active virus: a comparative analysis.

作者信息

Sammartino Josè Camilla, Vazzana Roberta, Cuscino Nicola, Castelbuono Salvatore, Giambruno Roberto, Carcione Claudia, Miceli Vitale, Bulati Matteo, Lilleri Daniele, Conaldi Pier Giulio, Baldanti Fausto, Gallo Alessia, Cassaniti Irene

机构信息

Department of Clinical-Surgical, Diagnostic and Pediatric Sciences, Università degli Studi di Pavia, Pavia, Italy.

Department of Research, IRCCS-ISMETT (Istituto Mediterraneo per i Trapianti e Terapie ad alta specializzazione), Palermo, Italy.

出版信息

J Transl Med. 2025 Mar 14;23(1):332. doi: 10.1186/s12967-025-06264-1.

DOI:10.1186/s12967-025-06264-1
PMID:40087733
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC11909907/
Abstract
摘要
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/96e9/11909907/f4ac5cbb3576/12967_2025_6264_Fig2_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/96e9/11909907/f70cc2e9d499/12967_2025_6264_Fig1_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/96e9/11909907/f4ac5cbb3576/12967_2025_6264_Fig2_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/96e9/11909907/f70cc2e9d499/12967_2025_6264_Fig1_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/96e9/11909907/f4ac5cbb3576/12967_2025_6264_Fig2_HTML.jpg

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本文引用的文献

1
Transcriptomic profiles of monocyte-derived macrophages exposed to SARS-CoV-2 VOCs reveal immune-evasion escape driven by delta.暴露于新冠病毒变异株的单核细胞衍生巨噬细胞的转录组图谱揭示了由德尔塔驱动的免疫逃逸。
J Transl Med. 2025 Feb 4;23(1):151. doi: 10.1186/s12967-025-06158-2.
2
Immunogenic properties of SARS-CoV-2 inactivated by ultraviolet light.经紫外线灭活的 SARS-CoV-2 的免疫原性。
Arch Virol. 2022 Nov;167(11):2181-2191. doi: 10.1007/s00705-022-05530-7. Epub 2022 Jul 20.
3
SARS-CoV-2 variants inactivation of plasma units using a riboflavin and ultraviolet light-based photochemical treatment.
SARS-CoV-2 变体使用基于核黄素和紫外线的光化学处理灭活血浆单位。
Transfus Apher Sci. 2022 Aug;61(4):103398. doi: 10.1016/j.transci.2022.103398. Epub 2022 Feb 16.
4
Impaired anti-SARS-CoV-2 humoral and cellular immune response induced by Pfizer-BioNTech BNT162b2 mRNA vaccine in solid organ transplanted patients.辉瑞-生物科技公司的BNT162b2 mRNA疫苗在实体器官移植患者中诱导的抗SARS-CoV-2体液免疫和细胞免疫反应受损。
Am J Transplant. 2021 Aug;21(8):2919-2921. doi: 10.1111/ajt.16702. Epub 2021 Jun 18.
5
PARP9 and PARP14 cross-regulate macrophage activation via STAT1 ADP-ribosylation.PARP9 和 PARP14 通过 STAT1 ADP-ribosylation 交叉调节巨噬细胞活化。
Nat Commun. 2016 Oct 31;7:12849. doi: 10.1038/ncomms12849.