Gijon-Nogueron Gabriel, Balint Peter, Batalov Anastas, Ostojic Predrag, Sollmann Nico, van Middelkoop Marienke, Agricola Rintje, Naili Josefine E, Milovanovic Darko, Popova Stanislava, Kazakova Maria, Nuernberger Sylvia, Aulin Cecilia, Karalilova Rositsa, Henrotin Yves
Department Nursing and Podiatry, University of Malaga, Malaga, Spain.
Musculoskeletal Radiology Group, Semmelweis University, Budapest, Hungary.
BMC Rheumatol. 2025 Mar 14;9(1):32. doi: 10.1186/s41927-025-00482-2.
Osteoarthritis (OA), a prevalent and disabling condition, significantly burdens individuals and healthcare systems worldwide. It is characterized by joint pain, stiffness, and structural changes in cartilage, bone, and synovium. The clinical manifestations of OA vary widely, reflecting complex interactions among genetic, metabolic, biomechanical, and environmental factors. Despite progress in identifying OA clinical phenotypes, inconsistent terminology, including "phenotypes," "subtypes," and "subgroups," hinders effective communication and research translation. This review aims to synthesize existing literature on clinical OA phenotypes, terminology, and definitions and propose a research agenda.
This scoping review followed PRISMA-ScR guidelines, focusing on publications from 2010 to 2023 investigating clinical phenotypes in adult OA patients. Searches were conducted in MEDLINE, SCOPUS, and EBSCOhost using combinations of terms related to clinical phenotypes in OA. Studies were screened, duplicates removed, and relevant data were charted and analyzed by two independent reviewers.
From 196 identified studies, 50 were included in the final analysis. Eight clinical phenotypes were categorized, including inflammatory, biomechanical, metabolic, and pain-sensitization. minimal joint disease, psychologically driven, menopause, severe radiographic. Most studies focused on knee OA, with limited exploration of hand, midfoot, and hip OA. Phenotype-based management strategies demonstrated potential for improving treatment outcomes and guiding research.
Standardizing terminology and leveraging phenotype-based frameworks hold promise for advancing personalized OA care and research. Future efforts should focus on validating criteria, developing accessible diagnostic tools, and addressing understudied OA phenotypes. This work highlights the value of tailoring interventions to specific OA phenotypes for improved patient outcomes.
Not applicable.
骨关节炎（OA）是一种常见且致残的疾病，给全球个人和医疗保健系统带来了沉重负担。其特征为关节疼痛、僵硬以及软骨、骨骼和滑膜的结构变化。OA的临床表现差异很大，反映了遗传、代谢、生物力学和环境因素之间复杂的相互作用。尽管在确定OA临床表型方面取得了进展，但包括“表型”“亚型”和“亚组”在内的术语不一致，阻碍了有效的交流和研究成果的转化。本综述旨在综合现有关于OA临床表型、术语和定义的文献，并提出一项研究议程。
本范围综述遵循PRISMA-ScR指南，重点关注2010年至2023年期间调查成年OA患者临床表型的出版物。在MEDLINE、SCOPUS和EBSCOhost中使用与OA临床表型相关的术语组合进行检索。由两名独立评审员对研究进行筛选、去除重复项，并对相关数据进行制表和分析。
从196项已识别的研究中，最终纳入50项进行分析。确定了八种临床表型，包括炎症性、生物力学性、代谢性和疼痛敏化性、轻度关节疾病、心理驱动型、绝经后型、重度影像学型。大多数研究集中在膝OA，对手、中足和髋OA的探索有限。基于表型的管理策略显示出改善治疗效果和指导研究的潜力。
标准化术语并利用基于表型的框架有望推动OA个性化护理和研究的发展。未来的工作应侧重于验证标准、开发易于使用的诊断工具以及解决研究不足的OA表型。这项工作强调了针对特定OA表型定制干预措施以改善患者预后的价值。
不适用。
