Department of Imaging and Functional Musculoskeletal Research, Institute of Anatomy and Cell Biology, Paracelsus Medical University Salzburg and Nuremberg, Salzburg, Austria; Department of Anatomy, Kathmandu University School of Medical Sciences (KUMS), Dhulikhel, Nepal.
Department of Imaging and Functional Musculoskeletal Research, Institute of Anatomy and Cell Biology, Paracelsus Medical University Salzburg and Nuremberg, Salzburg, Austria; Chondrometrics GmbH, Freilassing, Germany; Ludwig Boltzmann Institute for Arthritis and Rehabilitation (LBIAR), Paracelsus Medical University, Salzburg, Austria.
Osteoarthritis Cartilage. 2023 Oct;31(10):1396-1404. doi: 10.1016/j.joca.2023.07.007. Epub 2023 Jul 25.
To study the association of quantitative medial meniscal position measures with radiographic and symptomatic knee osteoarthritis (OA) progression over 2-4 years.
The FNIH OAI Biomarkers study comprised 600 participants in four subgroups: 194 case knees with combined structural (medial minimum joint space width (minJSW) loss ≥0.7 mm) and symptomatic (persistent Western Ontario and McMaster Universities Osteoarthritis Index (WOMAC) pain subscale increase ≥9 [0-100 scale]) progression; 200 knees with neither structural nor symptomatic progression; 103 knees with isolated structural and 103 with isolated symptomatic progression. Coronal double echo at steady state (DESS) MRIs were used for segmenting five central slices of the medial meniscus. Associations with progression were examined using logistic regression (adjusted for demographic and clinical data).
Greater baseline medial meniscal extrusion was associated with combined structural/symptomatic progression (OR 1.59; 95%CI: [1.25,2.04]). No relationship was observed for tibial plateau coverage or meniscal overlap distance. The two-year increase in meniscal extrusion (OR 1.48 [1.21, 1.83]), and reduction in tibial plateau coverage (OR 0.70 [0.58,0.86]) and overlap distance (OR 0.73 [0.60,0.89]) were associated with combined progression. Greater baseline extrusion was associated with isolated structural and less extrusion with isolated symptomatic progression. The longitudinal increase in meniscal extrusion, and reduction in tibial plateau coverage and overlap distance were associated with structural, but not with symptomatic progression.
Baseline measures of medial meniscal extrusion were consistently positively associated with combined radiographic/symptomatic progression and with isolated structural, but not with isolated symptomatic progression. These measures may therefore allow one to assess the risk of structural knee OA progression and to monitor interventions restoring meniscal position and function.
研究定量内侧半月板位置测量与放射学和症状性膝骨关节炎（OA）进展的相关性，随访时间为 2-4 年。
FNIH OAI 生物标志物研究包括 600 名参与者，分为四个亚组：194 例结构性（内侧最小关节间隙宽度（minJSW）损失≥0.7mm）和症状性（持续 Western Ontario 和 McMaster 大学骨关节炎指数（WOMAC）疼痛亚量表增加≥9[0-100 量表]）进展的病例膝关节；200 例无结构性和症状性进展的膝关节；103 例单纯结构性和 103 例单纯症状性进展的膝关节。使用冠状稳态双回波（DESS）MRI 对内侧半月板的五个中央切片进行分割。使用逻辑回归（调整人口统计学和临床数据）检查与进展的相关性。
基线时内侧半月板外突越大，与结构性/症状性进展相关（OR 1.59；95%CI：[1.25,2.04]）。胫骨平台覆盖或半月板重叠距离无相关性。半月板外突的两年增加（OR 1.48[1.21,1.83]），胫骨平台覆盖（OR 0.70[0.58,0.86]）和重叠距离（OR 0.73[0.60,0.89]）的减少与联合进展相关。基线时外突越大与孤立性结构进展相关，而外突越小与孤立性症状性进展相关。半月板外突的纵向增加，以及胫骨平台覆盖和重叠距离的减少与结构进展相关，但与症状性进展无关。
内侧半月板外突的基线测量值与放射学和症状性联合进展以及孤立性结构进展呈正相关，但与孤立性症状性进展无关。因此，这些测量值可能可以评估结构膝骨关节炎进展的风险，并监测恢复半月板位置和功能的干预措施。
