Armache Maria, Larson Alexis, Stemme Rachel, Walsh-Bailey Callie, Scott Kelli, Pearman Timothy, Stepan Katelyn O, Mierzwa Michelle L, Mady Leila J, Gharzai Laila A
Department of Otolaryngology, Johns Hopkins University, Baltimore, MD.
Department of Radiation Oncology, Northwestern University, Chicago, IL.
Semin Radiat Oncol. 2025 Apr;35(2):285-300. doi: 10.1016/j.semradonc.2025.02.003.
Long-term care for head and neck cancer (HNC) survivors is complex. Despite an improvement in survival and the evolution of treatment paradigms (de-escalation, targeted therapy), notably in the context of human papillomavirus (HPV)-related oropharyngeal cancers, HNC survivors still experience a wide range of side effects and needs, which impact their functionality, quality of life, survival and require concerted, coordinated survivorship care. In this review, we perform an overview of existing HNC survivorship recommendations within the context of novel evidence, our current understanding of survivorship care, and incorporate them into the Nekhluydov Survivorship Care Framework. This framework provides a novel way to appreciate and comprehensively address all aspects of HNC survivorship care. Further research is crucial to develop evidence-based, patient-centered personalized approaches to survivorship care in different HNC populations and understand barriers to successful implementation.
头颈部癌症（HNC）幸存者的长期护理很复杂。尽管生存率有所提高，治疗模式（降级、靶向治疗）也在不断演变，尤其是在人乳头瘤病毒（HPV）相关的口咽癌方面，但HNC幸存者仍会经历各种各样的副作用和需求，这会影响他们的功能、生活质量和生存率，因此需要协调一致的幸存者护理。在本综述中，我们结合新证据和当前对幸存者护理的理解，对现有的HNC幸存者护理建议进行了概述，并将其纳入Nekhluydov幸存者护理框架。该框架提供了一种全新的方式来认识和全面解决HNC幸存者护理的各个方面。进一步的研究对于开发基于证据、以患者为中心的个性化方法来应对不同HNC人群的幸存者护理以及了解成功实施的障碍至关重要。
