Department of Gastroenterology, The Second Affiliated Hospital, Harbin Medical University, Harbin, Heilongjiang 150086, China.
Department of Geriatrics, The Second Affiliated Hospital, Harbin Medical University, Harbin, Heilongjiang 150086, China.
Diabetes Res Clin Pract. 2019 May;151:120-127. doi: 10.1016/j.diabres.2019.04.012. Epub 2019 Apr 5.
Patients with hepatocellular carcinoma (HCC) having pre-existing type 2 diabetes (T2DM) have a poorer prognosis than those without T2DM. Moreover, accumulating evidence reveals that activated platelets play a crucial role in tumor and T2DM. The mean platelet volume (MPV) indicates platelet activation and is altered in malignancies. The present study aimed to investigate the clinical significance of MPV in patients with HCC having T2DM.
This retrospective study performed between January 2010 and December 2013 included 331 patients with HCC (165 with T2DM and 166 without T2DM). The overall survival was compared, and the predictors of overall survival were analyzed.
The patients with T2DM had lower MPV levels than those without T2DM. Furthermore, the MPV levels significantly differentiated T2DM from non-T2DM. In addition, for patients with T2DM, the overall survival was significantly shorter in patients with low MPV levels than in those with high MPV levels. Multivariate analysis identified decreased MPV as an independent prognostic factor for overall survival only in patients with T2DM, but not in those without T2DM.
Reduced MPV was a prognostic factor for poor outcome in patients with HCC and T2DM.
患有肝细胞癌 (HCC) 且合并有 2 型糖尿病 (T2DM) 的患者比未合并 T2DM 的患者预后更差。此外，越来越多的证据表明，活化的血小板在肿瘤和 T2DM 中发挥着关键作用。血小板平均体积 (MPV) 可反映血小板的活化状态，且在恶性肿瘤中发生改变。本研究旨在探讨合并 T2DM 的 HCC 患者中 MPV 的临床意义。
本回顾性研究于 2010 年 1 月至 2013 年 12 月进行，共纳入 331 例 HCC 患者（165 例合并 T2DM，166 例未合并 T2DM）。比较了总体生存率，并分析了总体生存率的预测因素。
合并 T2DM 的患者的 MPV 水平低于未合并 T2DM 的患者。此外，MPV 水平可显著区分 T2DM 和非 T2DM。此外，对于合并 T2DM 的患者，低 MPV 水平患者的总体生存率明显短于高 MPV 水平患者。多因素分析表明，仅在合并 T2DM 的患者中，MPV 降低是总体生存的独立预后因素，而在未合并 T2DM 的患者中则不是。
MPV 降低是合并 T2DM 的 HCC 患者预后不良的一个预测因素。
