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对加济安泰普(土耳其)地震后入住重症监护病房患者的临床特征及结局的评估:一项多中心观察性研究

Evaluation of the clinical characteristics and outcomes of patients admitted to intensive care units after the Kahramanmaras (Türkiye) earthquake: a multicenter observational study.

作者信息

Halacli Burcin, Guven Goksel, Kaya Esat Kivanc, Yildirim Mehmet, Bulut Yuksel Nihal Deniz, Kocak Gamze, Bulut Kadir, Gulen Derful, Erdemir Sullu Begum, Kilicaslan Banu, Seven Asir Eren, Gemcioglu Emin, Simsek Meltem, Yuksel Recep Civan, Temel Sahin, Kaynar Ahmet Safa, Deveci Kamil, Alptekinoglu Mendil Nilgun, Aydin Emre, Ulger Birkan, Esmaoglu Aliye, Boyaci Dundar Nazlihan, Ortac Ersoy Ebru, Gundogan Kursat, Akinci Seda Banu, Topeli Arzu

机构信息

Division of Intensive Care Medicine, Department of Internal Medicine, Hacettepe University Faculty of Medicine, Ankara, Türkiye.

Internal Medicine Intensive Care Unit, Ministry of Health, Mersin City Hospital, Mersin, Türkiye.

出版信息

Front Med (Lausanne). 2025 Feb 28;12:1517344. doi: 10.3389/fmed.2025.1517344. eCollection 2025.

Abstract

INTRODUCTION

The outcomes of patients admitted to intensive care units (ICUs) after earthquakes that occurred on the 6th of February 2023 in Türkiye are unknown. Our objective was to delineate the demographic and clinical characteristics, therapeutic approaches, and ICU outcomes of earthquake victims who were hospitalized in Turkish ICUs.

METHODS

This was a retrospective multicenter study of adult patients admitted to 12 ICUs across eight tertiary hospitals located in five different cities within 2 weeks after consecutive earthquakes. Clinical and laboratory data were documented at four specific time intervals: upon hospital admission and during the first, second, and third days of ICU admission. To identify independent predictors of ICU mortality, a binary logistic regression model was used for variables identified from the univariate analysis.

RESULTS

A total of 201 patients were admitted to ICUs. The median age of the entire cohort was 36 [26-54] years. 87 patients were male (43.3%), and 114 were female (56.7%). The majority of patients (79.1%) were initially admitted to the emergency department. The median duration of being trapped under the rubble was 12 [5-31] hours. The primary reason (63.7%) for ICU admission was crush syndrome. Acute kidney injury (AKI) was identified in 61.5% of patients. Of 201 patients, 184 had information regarding ICU survival. The ICU mortality rate was 10%. A five-year increase in age, the presence of crush syndrome, and the requirement for vasopressor therapy during ICU care were independently associated with increased ICU mortality rates, while an increase of one point in the Glasgow Coma Scale (GCS) score was favorable for ICU mortality.

CONCLUSION

This study demonstrated that crush syndrome accounted for 63.7% of the reasons for ICU admissions. The ICU mortality rate was recorded as 10%. Noteworthy independent risk factors for mortality were the presence of crush syndrome, increased age, vasopressor treatment and lower GCS score.

摘要

引言

2023年2月6日土耳其发生地震后,入住重症监护病房(ICU)的患者的治疗结果尚不清楚。我们的目的是描述在土耳其ICU住院的地震受害者的人口统计学和临床特征、治疗方法以及ICU治疗结果。

方法

这是一项回顾性多中心研究,研究对象为在连续地震后2周内入住位于五个不同城市的八家三级医院的12个ICU的成年患者。临床和实验室数据在四个特定时间点记录:入院时以及入住ICU的第一、第二和第三天。为了确定ICU死亡率的独立预测因素,对单因素分析中确定的变量使用二元逻辑回归模型。

结果

共有201名患者入住ICU。整个队列的中位年龄为36[26 - 54]岁。87名患者为男性(43.3%),114名患者为女性(56.7%)。大多数患者(79.1%)最初入住急诊科。被困在废墟下的中位时间为12[5 - 31]小时。入住ICU的主要原因(63.7%)是挤压综合征。61.5%的患者被诊断为急性肾损伤(AKI)。在201名患者中,184名有关于ICU生存的信息。ICU死亡率为10%。年龄每增加五岁、存在挤压综合征以及在ICU护理期间需要血管升压药治疗与ICU死亡率增加独立相关,而格拉斯哥昏迷量表(GCS)评分每增加一分对ICU死亡率有利。

结论

本研究表明,挤压综合征占ICU入院原因的63.7%。ICU死亡率记录为10%。值得注意的死亡独立危险因素是存在挤压综合征、年龄增加、血管升压药治疗和较低的GCS评分。

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