Erdogan Mehmet Mustafa, Erdogan Esra, Kocaman Nevin, Yasar Seyma, Kavak Songul Yerlikaya
Histology and Embryology Department, Sanliurfa Training and Research Hospital, Sanliurfa, Türkiye.
Faculty of Pharmacy, Basic Pharmaceutical Sciences Department, Harran University, Sanliurfa, Türkiye.
Arch Dermatol Res. 2025 Mar 17;317(1):574. doi: 10.1007/s00403-025-04099-w.
Non-melanoma skin cancer (NMSC) is the most prevalent malignancy worldwide, encompassing primarily BCC and SCC. Differentiating between these two carcinomas and distinguishing them from normal skin tissue can pose diagnostic challenges in certain cases. Adipokines, as regulators of various biological processes, have garnered attention for their potential roles in tumorigenesis. Asprosin (Asp) and Meteorin-like (Metrnl) are newly identified proteins implicated in several diseases, including cancer. Their potential contribution to the pathogenesis of skin cancers such as BCC and SCC remains underexplored. This study aimed to evaluate the expression profiles of Asp and Metrnl in BCC and SCC and to assess their potential utility as diagnostic biomarkers. The expression of Asp and Metrnl proteins was examined by immunohistochemical staining in biopsy samples from 60 control, 60 BCC, and 60 SCC cases obtained from the archive of the Pathology Laboratory of Malatya Turgut Ozal University Training and Research Hospital. Asp immunoreactivity was higher in BCC tissues compared to the other two groups, and it was statistically higher in SCC tissues compared to healthy control tissues. Metrnl immunoreactivity was also higher in BCC tissues compared to the other two groups, and statistically significant in SCC tissues when compared to healthy control tissues. The findings suggest that Asp and Metrnl proteins may serve as valuable biomarkers for distinguishing between BCC and SCC, the two most common non-melanoma skin cancers encountered in routine dermatopathology practice. These adipokines may also provide insights into the underlying pathophysiology of these malignancies, offering potential avenues for diagnostic and therapeutic advancements.
非黑色素瘤皮肤癌（NMSC）是全球最常见的恶性肿瘤，主要包括基底细胞癌（BCC）和鳞状细胞癌（SCC）。在某些情况下，区分这两种癌症并将它们与正常皮肤组织区分开来可能会带来诊断挑战。脂肪因子作为各种生物过程的调节因子，因其在肿瘤发生中的潜在作用而受到关注。阿朴脂蛋白（Asp）和类气象素（Metrnl）是新发现的与包括癌症在内的多种疾病有关的蛋白质。它们对BCC和SCC等皮肤癌发病机制的潜在贡献仍未得到充分研究。本研究旨在评估Asp和Metrnl在BCC和SCC中的表达谱，并评估它们作为诊断生物标志物的潜在效用。通过免疫组织化学染色检测了从马拉蒂亚图尔古特·奥扎尔大学培训与研究医院病理实验室存档中获取的60例对照、60例BCC和60例SCC病例的活检样本中Asp和Metrnl蛋白的表达。与其他两组相比，BCC组织中的Asp免疫反应性更高，与健康对照组织相比，SCC组织中的Asp免疫反应性在统计学上更高。与其他两组相比，BCC组织中的Metrnl免疫反应性也更高，与健康对照组织相比，SCC组织中的Metrnl免疫反应性具有统计学意义。这些发现表明，Asp和Metrnl蛋白可能是区分BCC和SCC的有价值的生物标志物，这两种是在常规皮肤病理学实践中最常见的非黑色素瘤皮肤癌。这些脂肪因子也可能为这些恶性肿瘤的潜在病理生理学提供见解，为诊断和治疗进展提供潜在途径。
