Department of Histology and Embryology, Firat University School of Medicine, Elazig, Turkey.
Department of Dermatology, Firat University School of Medicine, Elazig, Turkey.
Tissue Cell. 2022 Jun;76:101752. doi: 10.1016/j.tice.2022.101752. Epub 2022 Feb 4.
BCC (Basal Cell Carcinoma) and trichoblastoma are skin tumors originating from the hair follicle. BCC is the most common non-melanoma skin cancer. Differential diagnosis of BCC from trichoblastoma, which is a common benign tumor in terms of histology, morphology, and immunohistochemistry, is not possible. The effects of adipokines on tumorigenesis have attracted attention.
By examining the effects of Asprosin and Meteorine like peptide (METRNL) on these tumors, it is aimed to reach new information in the differential diagnosis of BCC and trichoblastoma. Twenty normal healthy tissue, 17 basal cell carcinoma and 12 trichoblastoma samples were included in the study.
Increased expression of Asprosin and METRNL was observed in tumor and stromal tissues in BCC. Although overexpression of METRNL was observed in the lesion area in trichoblastoma, no increase in Asprosin expression was observed. Asprosin and METRNL immunoreactivity were found to be statistically significantly higher in BCC samples compared to control and trichoblastoma.
Asprosin and METRNL can be used in the diagnosis of BCC. METRNL can be used in the diagnosis of trichoblastoma. These biomarkers are helpful for differentiation between BCC and trichoblastoma.
基底细胞癌（BCC）和毛母细胞瘤是起源于毛囊的皮肤肿瘤。BCC 是最常见的非黑色素瘤皮肤癌。BCC 从组织学、形态学和免疫组织化学上都是常见的良性肿瘤的毛母细胞瘤的鉴别诊断是不可能的。脂肪细胞因子对肿瘤发生的影响引起了人们的关注。
通过研究天冬酰胺酶和 Meteorine 样肽（METRNL）对这些肿瘤的影响，旨在为 BCC 和毛母细胞瘤的鉴别诊断提供新的信息。本研究纳入了 20 例正常健康组织、17 例基底细胞癌和 12 例毛母细胞瘤样本。
在 BCC 的肿瘤和基质组织中观察到天冬酰胺酶和 METRNL 的表达增加。虽然在毛母细胞瘤的病变区域观察到 METRNL 的过表达，但天冬酰胺酶的表达没有增加。与对照组和毛母细胞瘤相比，BCC 样本中天冬酰胺酶和 METRNL 的免疫反应性显著升高。
天冬酰胺酶和 METRNL 可用于 BCC 的诊断。METRNL 可用于毛母细胞瘤的诊断。这些生物标志物有助于区分 BCC 和毛母细胞瘤。
