Dunbar Mary, Agarwal Sonika, Venkatesan Charu, Vollmer Brigitte, Scelsa Barbara, Pardo Andrea C, Tarui Tomo, Hart Anthony R, Mulkey Sarah B, Lemmon Monica E, Gano Dawn
Department of Pediatrics, Hotchkiss Brain Institute, University of Calgary, Calgary, AB, Canada.
Division of Neurology & Pediatrics, Children's Hospital of Philadelphia; Division of Neurology, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, PA, USA.
Pediatr Res. 2025 Mar 18. doi: 10.1038/s41390-025-04000-5.
Fetal intracerebral hemorrhage is increasingly recognized on prenatal imaging. In this review, we discuss clinically relevant aspects of fetal intracerebral hemorrhage, including germinal matrix-intraventricular hemorrhage, as well as intraparenchymal hemorrhage. We discuss current clinical practice for prenatal counseling and postnatal management of fetal intracerebral hemorrhage, and offer practical recommendations for clinicians. We propose standardized terminology for classification of fetal intracerebral hemorrhage to be used in future research. We also highlight gaps in the literature and priorities for future research, namely the need for prospective large-scale studies to better understand underlying etiologies and neurodevelopmental outcomes in fetal intracerebral hemorrhage. IMPACT STATEMENT: We discuss the diverse etiologies and outcomes of fetal intracerebral hemorrhage, and propose standardized terminology for classification. We outline current practice and offer practical recommendations for management and counseling of fetal intracerebral hemorrhage, recognizing the need for capacity-building in the newly emerging subspecialty of fetal neurology. We highlight gaps in the literature and research priorities in fetal intracerebral hemorrhage to promote collaborative research, and the development of interventions to improve pregnancy and child outcomes.
胎儿颅内出血在产前影像学检查中越来越多地被发现。在本综述中,我们讨论了胎儿颅内出血的临床相关方面,包括生发基质 - 脑室内出血以及脑实质内出血。我们讨论了胎儿颅内出血产前咨询和产后管理的当前临床实践,并为临床医生提供实用建议。我们提出了用于胎儿颅内出血分类的标准化术语,以供未来研究使用。我们还强调了文献中的空白以及未来研究的重点,即需要进行前瞻性大规模研究,以更好地了解胎儿颅内出血的潜在病因和神经发育结局。影响声明:我们讨论了胎儿颅内出血的多种病因和结局,并提出了分类的标准化术语。我们概述了当前的实践,并为胎儿颅内出血的管理和咨询提供实用建议,认识到在新兴的胎儿神经学亚专业中进行能力建设的必要性。我们强调了胎儿颅内出血文献中的空白和研究重点,以促进合作研究,并开发改善妊娠和儿童结局的干预措施。