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梓醇(一种环烯醚萜苷)的多方面治疗潜力:最新综合综述

Multifaceted therapeutic potentials of catalpol, an iridoid glycoside: an updated comprehensive review.

作者信息

Hassan Mennat-Allah M, Fahmy Mohamed I, Azzam Hany N, Ebrahim Yasmina M, El-Shiekh Riham A, Aboulmagd Yara M

机构信息

Department of Pharmacology & Toxicology Department, Faculty of Pharmacy, Heliopolis University, Cairo, Egypt.

Department of Pharmacology and Toxicology, College of Pharmaceutical Sciences and Drug Manufacturing, Misr University for Science and Technology (MUST), Giza, Egypt.

出版信息

Inflammopharmacology. 2025 Mar 17. doi: 10.1007/s10787-025-01694-1.

Abstract

Catalpol, classified as an iridoid glucoside, is recognized for its significant role in medicine, particularly in the treatment of various conditions such as diabetes mellitus, neuronal disorders, and inflammatory diseases. This review aims to evaluate the biological implications of catalpol and the mechanisms underlying its diverse pharmacological effects. A thorough exploration of existing literature was conducted utilizing the keyword "Catalpol" across prominent public domains like Google Scholar, PubMed, and EKB. Catalpol has demonstrated a diverse array of pharmacological effects in experimental models, showcasing its anti-diabetic, cardiovascular-protective, neuroprotective, anticancer, hepatoprotective, anti-inflammatory, and antioxidant properties. In summary, catalpol manifests a spectrum of biological effects through a myriad of mechanisms, prominently featuring its anti-inflammatory and antioxidant capabilities. Its diverse pharmacological profile underscores its potential for therapeutic applications across a range of conditions. Further research is warranted to fully elucidate the clinical implications of catalpol and optimize its use in medical practice.

摘要

梓醇属于环烯醚萜苷类化合物,因其在医学领域的重要作用而受到认可,特别是在治疗糖尿病、神经疾病和炎症性疾病等各种病症方面。本综述旨在评估梓醇的生物学意义及其多种药理作用的潜在机制。利用 “梓醇” 这一关键词,在谷歌学术、PubMed和EKB等著名公共数据库中对现有文献进行了全面检索。梓醇在实验模型中展现出了多种药理作用,显示出其抗糖尿病、心血管保护、神经保护、抗癌、肝脏保护、抗炎和抗氧化特性。总之,梓醇通过多种机制表现出一系列生物学效应,其中抗炎和抗氧化能力尤为突出。其多样的药理特性突显了它在一系列病症治疗应用中的潜力。有必要进行进一步研究,以充分阐明梓醇的临床意义,并在医学实践中优化其使用。

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