Grimm Daniela, Corydon Thomas J, Sahana Jayashree, González-Torres Luis Fernando, Kraus Armin, Marchal Shannon, Wise Petra M, Simonsen Ulf, Krüger Marcus
Department of Microgravity and Translational Regenerative Medicine, Otto-von-Guericke-University, 39106 Magdeburg, Germany.
Research Group "Magdeburger Arbeitsgemeinschaft für Forschung unter Raumfahrt-und Schwerelosigkeitsbedingungen" (MARS), Otto-von-Guericke-University, 39106 Magdeburg, Germany.
Stem Cells Transl Med. 2025 Mar 18;14(3). doi: 10.1093/stcltm/szaf008.
The still young and developing space age, characterized by lunar and Martian exploration and the vision of extraterrestrial settlements, presents a unique environment to study the impact of microgravity (µg) on human physiology and disease development. Cancer research is currently a key focus of international space science, as µg fundamentally impacts cellular processes like differentiation, adhesion, migration, proliferation, survival, cell death, or growth of cancer cells as well as the cytoskeleton and the extracellular matrix (ECM). By creating three-dimensional (3D) tumor models in a µg-environment, like multicellular spheroids (MCS), researchers can expedite drug discovery and development, reducing the need for animal testing. This concise review analyses the latest knowledge on the influence of µg on cancer cells and MCS formation. We will focus on cells from brain tumors, lung, breast, thyroid, prostate, gastrointestinal, and skin cancer exposed to real (r-) and simulated (s-) µg-conditions.
仍处于年轻且不断发展阶段的太空时代，其特点是进行月球和火星探索以及拥有外星定居点的愿景，为研究微重力（µg）对人体生理学和疾病发展的影响提供了独特的环境。癌症研究目前是国际空间科学的一个关键重点，因为微重力从根本上影响细胞过程，如癌细胞的分化、黏附、迁移、增殖、存活、细胞死亡或生长，以及细胞骨架和细胞外基质（ECM）。通过在微重力环境中创建三维（3D）肿瘤模型，如多细胞球体（MCS），研究人员可以加快药物发现和开发，减少动物试验的需求。这篇简短的综述分析了关于微重力对癌细胞和MCS形成影响的最新知识。我们将重点关注暴露于真实（r-）和模拟（s-）微重力条件下的来自脑肿瘤、肺癌、乳腺癌、甲状腺癌、前列腺癌、胃肠道癌和皮肤癌的细胞。
