Hui Tianxiao, Zhou Jian, Yao Muchen, Xie Yige, Zeng Hu
State Key Laboratory of Gene Function and Modulation Research, College of Future Technology, Peking-Tsinghua Center for Life Sciences, Peking University, Beijing, 100871, China.
Peking-Tsinghua Center for Life Sciences, Tsinghua University, Beijing, 100084, China.
Small Methods. 2025 May;9(5):e2401171. doi: 10.1002/smtd.202401171. Epub 2025 Mar 18.
Rapidly developing spatial omics technologies provide us with new approaches to deeply understanding the diversity and functions of cell types within organisms. Unlike traditional approaches, spatial omics technologies enable researchers to dissect the complex relationships between tissue structure and function at the cellular or even subcellular level. The application of spatial omics technologies provides new perspectives on key biological processes such as nervous system development, organ development, and tumor microenvironment. This review focuses on the advancements and strategies of spatial omics technologies, summarizes their applications in biomedical research, and highlights the power of spatial omics technologies in advancing the understanding of life sciences related to development and disease.
快速发展的空间组学技术为我们深入了解生物体内细胞类型的多样性和功能提供了新方法。与传统方法不同，空间组学技术使研究人员能够在细胞甚至亚细胞水平剖析组织结构与功能之间的复杂关系。空间组学技术的应用为神经系统发育、器官发育和肿瘤微环境等关键生物学过程提供了新视角。本文综述聚焦于空间组学技术的进展和策略，总结其在生物医学研究中的应用，并突出空间组学技术在推动与发育和疾病相关的生命科学理解方面的强大作用。
