Liang Shuya, Xing Jiyao, Zhang Zongying, Wang Dan, Xing Dongming, Geng Zhongmin
Department of Dermatology, The Affiliated Hospital of Qingdao University, Qingdao, 266071, China.
Cancer Institute, The Affiliated Hospital of Qingdao University, Qingdao University, Qingdao, 266071, China.
Small. 2025 Apr;21(17):e2500207. doi: 10.1002/smll.202500207. Epub 2025 Mar 18.
Post-operative surgical wound monitoring remains a significant clinical challenge in preventing bacterial infection. Current methods rely on indirect observations or costly investigations, often detecting infections only after complications arise. Here the medical sutures coated with Janus-type nanomotors (Pt-MOFs) with infected microenvironment-responsive properties for monitoring and treating surgical site infections are prepared. The Pt-MOFs nanomotors exhibit efficient self-propulsion with enhanced penetration and diffusion in biofilms by catalyzing hydrogen peroxide to produce oxygen bubbles. Copper ions serve dual roles as structural nodes and Fenton-like catalysts, generating antibacterial hydroxyl radicals while forming non-emissive self-aggregates. Here in vitro is shown that Pt-MOFs nanomotors present excellent bacterial imaging and enhanced antibacterial activity against both Gram-positive and Gram-negative bacteria. As a proof of concept, Pt-MOFs nanomotors coated surgical sutures successfully monitor the process of Staphylococcus aureus-infected wounds on mouse model. Furthermore, in vivo studies testify that Pt-MOFs nanomotors play an important role in treating infected surgical wounds through mitigating inflammatory infiltrates, facilitating collagen deposition and accelerating reepithelialization. This combined monitoring and treatment approach offers a promising strategy for surgical wound healing.
术后手术伤口监测仍然是预防细菌感染的一项重大临床挑战。目前的方法依赖于间接观察或昂贵的检查，通常只有在并发症出现后才能检测到感染。在此，制备了涂有具有感染微环境响应特性的Janus型纳米马达（Pt-MOFs）的医用缝线，用于监测和治疗手术部位感染。Pt-MOFs纳米马达通过催化过氧化氢产生氧气气泡，表现出高效的自推进能力，并在生物膜中具有增强的渗透和扩散能力。铜离子作为结构节点和类芬顿催化剂发挥双重作用，在形成非发光自聚集体的同时产生抗菌羟基自由基。体外实验表明，Pt-MOFs纳米马达具有出色的细菌成像能力，对革兰氏阳性菌和革兰氏阴性菌均具有增强的抗菌活性。作为概念验证，涂有Pt-MOFs纳米马达的手术缝线成功地监测了小鼠模型上金黄色葡萄球菌感染伤口的过程。此外，体内研究证明，Pt-MOFs纳米马达通过减轻炎症浸润、促进胶原蛋白沉积和加速上皮再形成，在治疗感染的手术伤口中发挥重要作用。这种联合监测和治疗方法为手术伤口愈合提供了一种有前景的策略。
